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ORIGINAL ARTICLE
Korean J Pediatr 1995 July;38(7) :907-913.
Clinical Studies of Measles in Infancy - Emphasizing on Measles Specific IgG Antibody -
Jae Ho Lee (Lee JH), Shin Hye Moon (Moon SH)
Department of Pediatrics, College of Medicine Chungnam National University, Taejon, Korea
Copyright © 1995 by The Korean Pediatric Society
ABSTRACT
Purpose : This study was investigated the efficacy of maternal measles specific IgG antibody and the optimal age for measles vaccination in susceptable infant during epidemics Methods : We evaluated the clinical manifestations and complications of 50 measles infants who were clinically and serologically diagnosed as measles and had not been vaccinated acco-rding to the presense of measles specific IgG antibody from Nov.1993 to Jan.1994 in Taejon. Results : 1) Out of 50 patients, 31 patients(62%) were measles specific IgG antibody positive (positi-ve group) and 19 patients(38%) were measles specific IgG negative (negative group). Peak age of measles patients were each 7 - 9 month old in positive group and 5-7 month old in negative group(p>0.05). 2) Fever usually developed 2 days prior to the appearance of rash in both positive and negative group. Duration of fever was less than 3 days in 18 cases(58%) of positive group and 4 - 6 days in 12 cases(63%) of negative group(p>0.05). 3) Duration of cough was more than 10 days in 24 cases(77%) of positive group and 7 cases(37%) of negative group(p<0.05). 4) Complications such as pneumonia, otitis media, gastroenteritis, and hepatitis were noted in 39 cases(78%) of all patients and more common in positive group (p>0.05). Conclusion : Clinical manifestations and complications were not significantly differed betw-een measles specific IgG positive group and negative group in this study. Measles specific IgG antibody was not detected from 5 month old infants and measles could be infected from 5 mo-nths of age. Early vaccination should be recommended on this age during measles epidemics and revaccination should also be done at 15 month old age.
Keywords: Measles | Maternal measles specific IgG | Vaccination
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