Advanced Search
ORIGINAL ARTICLE
Korean J Pediatr 1995 July;38(7) :955-962.
Effects of Cyclosporine on the Renal Sympathetic Nerve Activity and Baroreflex Function in Rabbits
Chan Uhng Joo (Joo CU), Tae Hee Park (Park TH), Moon Hwan Lee (Lee MH), Jung Soo Kim (Kim JS)
Department of Pediatrics, School of Medicine, Institute for Medical Science Chonbuk National University, Chonju, Korea
Copyright © 1995 by The Korean Pediatric Society
ABSTRACT
Purpose : The immunosuppresive drug cyclosporine(CS) is a novel agent that has greatly enhanced long-term survival after organ transplantation and has proved beneficial in the treat-ment of many autoimmune diseases. However, CS has emerged as a new cause of hypertens-ion. Although the causes of the hypertension are undoubtedly multifactorial, there are evidenc-es to suggest that sympathetic overactivity is involved. We postulate that hypertension associa-ted with CS is due to an upward resetting in sympathetic nerve activity which is seen in angio-tensin II induced hypertension. The purpose of this study is to evaluate the effects of cyclosp-orine on the renal sympathetic nerve activity and baroreflex function. Methods : Studies were performed in conscious rabbits(n=12) previously instrumented with arterial and venous catheters and renal nerve electrodes. Arterial baroreflex curves relating renal sympathetic nerve activity (RSNA) and heart rate(HR) to mean arterial pressure(MAP) were determined by producing ramp increased(i.v. phenylephrine) and decreases(i.v. nitroglyc-erin)in MAP. Results : In rabbits, CS(20 mg/kg i.v. 30 mm) produced significant increases in RSNA(100 to 181.3 10.3%, p<0.05), but did not increase MAP or HR. CS treatment produced a shift of the mid-range of the baroreflex control of RSNA(78.91 4.14 to 92.5 3.67) and of HR(80.18 3.9 to 95.4 13.9). CS had no effect on the maximum value of RSNA, or maximum gains of the these reflexes. Conclusion : These data suggests that the sympathoexcitatory response to CS involves an upward resetting of the arterial baroreflex function.
Keywords: Cyclosporine | Sympathetic nervous system | Baroreflex
TOOLS
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
Supplementary Material  Supplementary Material
  E-Mail
  Print
Share:      
METRICS
891
View
0
Download
Effects of lamotrigine on attention-deficit hyperactivity disorder in pediatric epilepsy patients  2017 June;60(6)
The Effect of Low-Dose Dopamine on the Renal Function of Asphyxiated Neonates  1998 December;41(12)
Register for e-submission
Register here to access the e-submission system of Korean J Pediatr for authors and reviewers.
Manuscript Submission
To submit a manuscript, please visit the Korean J Pediatr e-submission management system at http://submit.kjp.or.kr, read the Instructions for Authors, and log into the Korean J Pediatr e-submission system. For assistance with manuscript submission, please contact: kjpped@gmail.com.
Free archive
Anyone may access any past or current articles without logging in.
Korean Pediatric Society Office
#1606, Seocho World Officetel, 19 Seoun-ro, Seocho-gu, Seoul 137-070, Korea
TEL : +82-2-3473-7305    FAX : +82-2-3473-7307   E-mail: kjpped@gmail.com
BrowseCurrent IssueFor Authors and ReviewersAbout
Copyright© The Korean Pediatric Society. All right reserved.