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ORIGINAL ARTICLE
Korean J Pediatr 1995 July;38(7) :970-975.
Study on Anti-neutrophil Cytoplasmic Antibodies in Children with Henoch-Schölein Purpura
Shin Jong Lee (Lee SJ)1, Woo Yeong Chung (Chung WY)1, Chul Ho Kim (Kim CH)1, Jeong Nyeo Lee (Lee JN)2
1Department of Pediatrics, Pusan Paik Hospital, College of Medicine, Inje University, Pusan, Korea
2Department of Clinical Parthology, Pusan Paik Hospital, College of Medicine, Inje University, Pusan, Korea
Copyright © 1995 by The Korean Pediatric Society
ABSTRACT
The presence of IgG, IgA and IgM antineutrophil cytoplasmic antibodies(ANCA) were inves-tigated in 32 children with Henoch-Schölein Purpura(HS purpura), in 14 children with HS pur-pura nephritis who were confirrned by renal biopsy and in 12 control children using flow cytom-etry(FASCan, Beckton-Dickinson, Co, USA) and indirect immunofluorescence technique(Sigma Diagnostics, USA). There were no evidence of IgG, IgA or IgM cytoplasmic ANCA(p-ANCA), and perinuclear ANCA(c-ANCA) in the sera of 32 children. These results suggest that ANCA are not involved in the pathogenesis of vasculitis in HS purpura & HS purpura nephritis.
Keywords: Henoch-Schölein purpura | Anti-neutrphil cytoplasmic antibodies
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