Advanced Search
Korean J Pediatr 1995 July;38(7) :988-992.
A Case of Disseminated Pagetoid Reticulodsis
Hyang Mi Kwon (Kwon HM)1, Sun Seong Park (Park SS)1, Hye Lim Jung (Jung HL)1, Dong Hyuck Keum (Keum DH)1, Kye Yong Song (Song KY)2
1Department of Pediatrics, Koryo General Hospital, Seoul Korea
2Department of Anatomical Pathology, Chung Ang University College of Medicine, Seoul, Korea
Copyright © 1995 by The Korean Pediatric Society
Pagetoid reficulosis is a rare skin disorder consisting of localized(WoringerKolopp type) or disseminated (Ketron-Goodman type), asymptomatic hyperkeratotic, cutaneous plaque. The disseminated form has clinical similarities with mycosis fungoides and histologically characteri-sed by prominent infiltration of cytologically atypical mononuclear cells within a hyperplastic epidermis. It is suggested that the infiltrating cells orginate from T-lymphocytes. A 6yr old male patient visited with slowly disseminating, multiple erythematous skin rashes on whole body for one year. Skin biopsy showed dense infiltration of atypical mononuclear cells and lymphocytes within lower portion of epidermis. Dermal mononuclear cells are small but epidermal mononuclear cells are large lymphoreticular cells. Large lymphoreticular cells in epi-dermis show convoluted nucleus with prominent nucleoli and abundant cytoplasm. Immunohist-ologic studies were taken with Pan-T, Lysozyme, LCA(Leukocyte Common Antigen), 5-100. The mature lymphoid cells infiltrated in dermis showed positive reaction with Pan-T and Lyso-zyme, but atypical mononuclear cells infiltrated in epidermis showed negative reaction with all immunohistochemical stains. Electronmicroscopic finding of large cells show only few electron dense granules and poorly developed microorganells. With above feature we concluded that dermal lymphoid cells are reactive non neoplastic cells, while epidermal cells are neoplastic and T-cell lineage. Systemic chemotherapy was done and then he improved clinically.
Keywords: Pagetoid reticulosis | T-lymphocyte | Chemotherapy
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
Supplementary Material  Supplementary Material
A Case of Hemolytic Disease in a Newborn Due to Anti-Jkb  2003 July;46(7)
A Case of Cystinosis  2003 June;46(6)
Two Cases of Disseminated Intravascular Coagulation Due to Status Epilepticus with High Fever  2001 September;44(9)
A Case of Transient Neonatal Pustular Melanosis  1999 June;42(6)
A Case of Pulmonary Paragonimiasis  1999 March;42(3)
Register for e-submission
Register here to access the e-submission system of Korean J Pediatr for authors and reviewers.
Manuscript Submission
To submit a manuscript, please visit the Korean J Pediatr e-submission management system at, read the Instructions for Authors, and log into the Korean J Pediatr e-submission system. For assistance with manuscript submission, please contact:
Free archive
Anyone may access any past or current articles without logging in.
Korean Pediatric Society Office
#1606, Seocho World Officetel, 19 Seoun-ro, Seocho-gu, Seoul 137-070, Korea
TEL : +82-2-3473-7305    FAX : +82-2-3473-7307   E-mail:
BrowseCurrent IssueFor Authors and ReviewersAbout
Copyright© The Korean Pediatric Society. All right reserved.