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Korean J Pediatr 1995 September;38(9) :1176-1184.
Serum 2-microglobulin and Retinol Binding Protein and Urine 2-microglobulin and 1-microglobulin in Early Neonatal Period
Jong Duck Kim (Kim JD)1, Jae Kak Choi (Choi JK)2, Yong Hwoe Moon (Moon YH)1
1Department of Pediatrics, College of Medicine, Wonkwang University, I-Ri, Korea
2Department of Clinical Pathology College of Medicine, Wonkwang University, I-Ri, Korea.
Copyright © 1995 by The Korean Pediatric Society
Purpose : For evaluation of usefulness of the serum .2-microglobulin(B2MG), retinol binding protein(RBP), urine 1-microglobulin(A1MG), and B2MG on neonatal renal function and renal tubular injuries, we detected and compared these values in 20 neonates. Methods : They were grouped into premature neonate, gestational age was 30-50 weeks(group ), and full term neonate, gestational age was 38-40 weeks(group ), The group was subdivided into 5 normal full term neonate(group N)and 5 as phyxiated neonate(group A) whose 1 min apgar score was below 4. We detected the values of serum RBP, B2MG, urine A1MG, and B2MG on these neonates. Using these values, the clearence of B2MG and fractional excretion of B2MG were estimated Results : 1) The mean birth weight was 2.005gm in the group and the mean 1 min. Apgar score 6.9 in the group and 2.8 in the group A. 2) The mean values of serum RBP were 0.160.06 mg/L in the group , 1.190.07 mg/L in the group A,.and 0.150.03 mg/L in the group N respectively. 3) The mean values of serum B2MG were 2.530.78 mg/L in the group , 2.39 0.91 mg/L in the group A, and 3.982.5 mg/L in the group EN respectively. 4) The mean values of urine A1MG were 25.3411.06 mg/L in the group , 31.80 21.21 mg/L in the group A, and 28.5017.80 mg/L in the group N respectively. 5) The mean values of urine B2MG were 2.410.98 mg/L in the group , 2.810.80 mg/L in the group A, and 2.491.09 in the group N respectively. 6) The clearance of B2MG was significantly high in group A compared with group (p<0.05). 7) The fractional excretion of B2MG (FEB2MG) was high in the group A compared with the group and the group N (p<0.05). Conclusion : It is concluded that we can uses the value of serum B2MG and RBP in the premature and full nterrm neonate as a normal reference value, and the values of the clearance of B2MG and FEB2MG as a predicting the hypoxic damage of renal proximal tubules in the asphyxiated neonate.
Keywords: 2-microglobulin | Retinol Binding Protein | 1-microglobulin
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