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Korean J Pediatr 1997 July;40(7) :981-990.
Urinary Interleukin-1 Levels in Children with Urinary Tract Infection
Kyung Hyo Kim (Kim KH), Young Mi Hong (Hong YM), Gyoung Hee Kim (Kim GH)
Department of Pediatrics, College of Medicine, Ewha Woman`s University, Seoul, Korea
Copyright © 1997 by The Korean Pediatric Society
Purpose : IL-1 and TNF- are important mediators of the inflammatory response in serious bacterial infections. The mucosal and systemic IL-1 and TNF- responses to urinary tract infection are analyzed in children with acute urinary tract infection. Methods : We studied the levels of these two cytokines in the urine and sera of 21 children at diagnosis and after treatment with sandwich ELISA method. Results : The mean urinary IL-1 level in acute UTI was 3.9pg/ml compared with 1.5pg/ml in febrile group and 1.6pg/ml in the normal control group(p< 0.05). TNF- was not elevated in urine in children with UTI or other groups. These results suggest that bacteriuria is accompanied by elevated urinary IL-1 levels and that this IL-1 may be locally produced. Conclusion : IL-1 is elevated in urine of children with urinary tract infection. This may be due to a local inflammatory response in the urinary tract. Variation in local cytokine production with time and the clinical significance of these observations require further study.
Keywords: Urinary tract infection | IL-1
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