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Korean J Pediatr 1997 July;40(7) :1021-1025.
A Case of Chronic Granulomatous Disease Which is Improved by Interferon- Therapy
Jae Choon Kim (Kim JC), Soon Seong Park (Park SS), Myung Ja Yun (Yun MJ), Dong Hyuk Keum (Keum DH)
Department of Pediatrics, Kangbuk Samsung Hospital, Seoul, Korea
Copyright © 1997 by The Korean Pediatric Society
Chronic granulomatous disease is a group of rare disorders characterized by a disease of oxidative metabolism of phagocytes with deficit of antimicrobial activity. Also, it has clinical features of chronic pyogenic infection, granuloma formation, hypergammaglobulinemia, anemia and leukocytosis. We experienced a case of chronic granulomatous disease with chronic recurrent infection, hypergammaglobulinemia and liver abscess. It was confirmed by modified NBT test. The result of patient' s NBT test was less than 11%. The patient received subcutaneous injection of interferon-, 200 million unit(0.1mg/m2 of body surface area per dose), on three consecutive days per week for 3 weeks and her symptom was improved. Then, we report a case of chronic granulomatous disease which is improved by interferon- therapy with brief review of literature.
Keywords: Chronic granulomatous disease | Interferon- therapy
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