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ORIGINAL ARTICLE
Korean J Pediatr 2003 September;46(9) :876-882.
Myocardial Protective Effect of Cardioxane for the Myocardial Damage due to Doxorubicin
Hee-Ju Park (Park HJ)1, Jai-Min Oh (Oh JM)1, Sung-Hoon Kim (Kim SH)1, Chang-Hoon Lee (Lee CH)2, Sang-Sik Kim (Kim SS)3
1Department of Pediatrics, College of Medicine, Pusan National University, Busan, Korea
2Department of Surgical Pathology, College of Medicine, Pusan National University, Busan, Korea
3Department of Technician of Electronic Microscopy, College of Medicine, Pusan National University, Busan, Korea
Corresponding Author: Hee-Ju Park ,Email: phj7294@hanmail.net
Copyright © 2003 by The Korean Pediatric Society
ABSTRACT
Purpose : To find out the myocardial protective effect of cardioxane for the myocardial damage by doxorubicin. Methods : Using Eighteen rabbits(2.0-3.2 kg), doxorubicin(30 mg/m2) was injected intravenously once a week in group I(12 rabbits) and cardioxane(600 mg/m2) was injected at 20-30 minutes before doxorubicin administration in group II(6 rabbits). After this, we operated on the rabbits when the total cumulative dose of doxorubicin was reached at 210, 240, 270 and 300 mg/m2 and observed the degree of myocardial damage with light and electronic microscope. Results : In group I, rabbits with less than 210 mg/m2 of total cumulative dose of doxorubicin, there was no definite myocardial damage but with 240 mg/m2, focal degenerative change was observed and with 300 mg/m2, severe degenerative change was detected with light microscopic examination. With electronic microscope, rabbits with less than 180 mg/m2 of total cumulative dose of doxorubicin in group I, there was no evidence of myocardial damage. In 210 mg/m2, focal degenerative change was detected. With 240 mg/m2, degenerative change was much more advanced and with 300 mg/m2, severe degenerative change was detected. In group II, no definite myocardial damage was observed even though the total cumulative dose of doxorubicin reached 300 mg/m2, but with 360 mg/m2, there was a focal area where myocardial fibers were somewhat decreased, but it's difficult to say whether these decrement were due to adriamycin in the electronic microscopic examination. Conclusion : Cardioxane have a good protective effect for the doxorubicin induced cardiomyopathy and it will be used safely in pediatric cancer patients.
Keywords: Cardioxane | Doxorubicin | Myocardial degenerative change
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