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Korean J Pediatr 2003 December;46(12) :1207-1211.
Plasma L-Arginine Concentration, Oxygenation Index and Pulmonary Artery Pressure in Premature Infants with Respiratory Distress Syndrome
Kyong Ah Jeong (Jeong KA), Soon Ju Lee (Lee SJ), In Kyung Sung (Sung IK), Chung Sik Chun (Chun CS)
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea
Corresponding Author: Soon Ju Lee ,Email:
Copyright © 2003 by The Korean Pediatric Society
Purpose : This study was performed to observe the relationship of plasma L-arginine level and the severity of disease and pulmonary artery pressure in respiratory distress syndrome of premature infants. Methods : Peripheral blood samples were obtained at 1st, 3rd and 7th day from 21 premature infants with respiratory distress syndrome to analyze the L-arginine concentration. Oxygenation index (OI), an indicator of the severity of the disease, was calculated at the same time of the blood sampling. And pulmonary artery pressure was measured by Doppler echocardiography at each period. Plasma L-arginine level, OI and right ventricular systolic time interval(RVSTI) were analyzed. Results : Plasma L-arginine concentration of the 1st day was lower than 3rd and 7th day. OI and RVSTI were significantly correlated with each other(r=0.772, P<0.01). Plasma L- arginine level was correlated with oxygenation index(r=-0.346, P<0.01) and RVSTI(r=-0.416, P<0.01). Conclusion : Plasma L-arginine level was lowest in the 1st day during the study period. Plasma L- arginine concentration correlated significantly with the severity of respiratory distress syndrome and pulmonary artery pressure in premature infants.
Keywords: RDS | L-arginine | Oxygenation index | Pulmonary artery pressure
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The pharmacological treatment of patent ductus arteriosus in premature infants with respiratory distress syndrome: oral ibuprofen vs. indomethacin  2008 September;51(9)
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Doppler Echocardiographic Assessment of the Changes in Pulmonary Arterial Pressure in Preterm Infants with Respiratory Distress Syndrome  1999 June;42(6)
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Influences of the Intrapulmonary RL Shunt on PaO2 and PaCO2 after Instillation of Exogenous Pulmonary Surfactant to Premature Neonates with Respiratory Distress Syndrome  1997 November;40(11)
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