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Korean J Pediatr 2004 February;47(2)
The Effect of Histologic Chorioamnionitis on the Development of Respiratory Distress Syndrome and Chronic Lung Disease in Preterm Infants
Heui seung Jo (Jo HS)1, Beyong Il Kim (Kim BI)2, Chang Won Choi (Choi CW)2, Jun Dong Park (Park JD)2, Chong Jai Kim (Kim CJ)3, Jung-Hwan Choi (Choi JH)2
1Department of Pediatrics, College of Medicine, Inje University, Ilsan, Korea
2Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
3Department of Pathology, College of Medicine, Seoul National University, Seoul, Korea
Corresponding Author: Beyong Il Kim ,Email: beyil@snu.ac.kr
Copyright © 2004 by The Korean Pediatric Society
ABSTRACT
Purpose : Histologic chorioamnionitis may play a role in the development of respiratory distress syndrome(RDS) and chronic lung disease(CLD) independently or through its association with preterm birth. We investigated the relationship between histologic chorioamnionitis and clinical complications including, RDS and CLD, of preterm infants. Methods : Clinical data were collected retrospectively from 478 preterm infants(gestational period34 weeks) who were admitted to the neonatal intensive care unit(NICU) in Seoul National University Children's Hospital from January 1993 to December 2000. Results : Histologic chorioamnionitis(CA) was observed in 210 of 478 infants(44%). Lower gestational period was detected in CA() group(31122 weeks vs. 30123 weeks). CA() group had decreased incidence of RDS(38.4% vs. 28.1%)[odds ratio, OR 0.35(P=0.0004, 95% confidence intervals, CI 0.19-0.63)], and increased incidence of CLD(7.5% vs. 13.3%)[OR 1.95(P=0.047, 95% CI 1.01-3.79)] combined much more "atypical CLD"(10.5% vs. 55.6%). CA() group had decreased incidence of patent ductus arteriosus(33.3% vs. 25.4%)[OR 0.37(P=0.003, 95% CI 0.19-0.71)]. There was no difference between the two groups in birth weight. Conclusion : It is suggested that intrauterine infections and fetal inflammatory responses might play a role in the outcome of preterm infants, and histologic chorioamnionitis is an isolated risk factor in the development of RDS and CLD of the preterm infants.
Keywords: and histologic chorioamnionitis is an isolated risk factor in the development of RDS and CLD of the preterm infants."
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