Advanced Search
Korean J Pediatr 2004 November;47(11) :1137-1141.
Role of Mast Cells in Allergic Inflammation and Innate Immunity
Kangmo Ahn (Ahn KM)
Department of Pediatrics, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea
Corresponding Author: Kangmo Ahn ,Email:
Copyright © 2004 by The Korean Pediatric Society
Mast cells play a key role in elicitation of the early-phase and late-phase IgE-mediated allergic inflammatory reactions. Mast cells are derived from pluripotent stem cells from the bone marrow. These cells migrate through circulation into connective tissues and mucosal surfaces where they mature. On the cell surfaces, mast cells have high affinity IgE receptor(FcRI), which react with specific IgE to secrete preformed and newly synthesized mediators within minutes or over a period of hours. For human mast cells, two subtypes have been recognized by the distribution of granular neutral proteases. TC-type mast cells(MCTC) contain tryptase together with chymase, cathepsin-G, and carboxypeptidase, while T-type mast cells(MCT) contain tryptase only. They also produce Th2- type cytokines to persist chronic allergic inflammation in local tissues. Mast cells have been widely studied in the context of allergic reactions and parasite infections, but there is growing evidence that they participate in innate immunity, wound healing, fibrosis, remodelling and autoimmune disease. Much research works are expected to be underwent by the development of in vitro culture system of human mast cells in addition to mast cells obtained from animals, human biopsy or cell lines. In conclusion, it is clear that mast cells are pleiotropic, multipotential and complex. More detailed research remains to be needed for further understanding of biology of mast cells and it will be helpful to develop novel treatment modality in allergic inflammation.
Keywords: Mast cells | Allergy | Immunity
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
Supplementary Material  Supplementary Material
Infection and Innate Immunity  2005 November;48(11)
The Role of Basophils in the Mechanism of Allergic Inflammation  2003 June;46(6)
The Role of Proteinases in Tumor Invasion and Metastasis  1997 July;40(7)
Role of Cytokines in Allergic Diseases  1994 June;37(6)
Register for e-submission
Register here to access the e-submission system of Korean J Pediatr for authors and reviewers.
Manuscript Submission
To submit a manuscript, please visit the Korean J Pediatr e-submission management system at, read the Instructions for Authors, and log into the Korean J Pediatr e-submission system. For assistance with manuscript submission, please contact:
Free archive
Anyone may access any past or current articles without logging in.
Korean Pediatric Society Office
#1606, Seocho World Officetel, 19 Seoun-ro, Seocho-gu, Seoul 137-070, Korea
TEL : +82-2-3473-7305    FAX : +82-2-3473-7307   E-mail:
BrowseCurrent IssueFor Authors and ReviewersAbout
Copyright© The Korean Pediatric Society. All right reserved.