Advanced Search
ORIGINAL ARTICLE
Korean J Pediatr 2004 November;47(11) :1205-1209.
Urine Organic Acid Analysis of Patients with Febrile Seizures
Dong Soo Shin (Shin DS), Gun Jun Lee (Lee GJ), Kyeung Ja Lee (Lee KJ), Won Il Park (Park WI), Eun Joo Bae (Bae EJ), Hong Gin Lee (Lee HG)
Department of Pediatrics, College of Medicine, Hallym University, Chunchon, Korea
Corresponding Author: Hong Gin Lee ,Email: hongjlee@hallym.ac.kr
Copyright © 2004 by The Korean Pediatric Society
ABSTRACT
Purpose : Febrile seizure, the most common seizure disorder in children between 6 months and 5 years of age, is mostly caused by viral infections, except severe CNS infection. It can also be caused by disorders in organic acid metabolism, especially accompanied by fever. Therefore we decided to investigate the relationship between children with febrile seizures and disorders in organic acid metabolism. Methods : We examined 54 children with febrile seizure who visited Chunchon Sacred Heart Hospital Emergency Department from February 2002 to January 2004. We conducted urine organic acid analysis, CBC, urine analysis, serum ammonia and gas analysis. Results : Thirteen(24.1%) patients showed ketonuria, eight(14.8%) patients showed lactic aciduria and ketonuria, two(3.7%) patients showed pyruvic aciduria, and one(1.8%) showed mandelic aciduria. Conclusion : Twenty four of 54(44.4%) showed abnormal findings in urine organic acid analysis. Most results are ketonuria or lactic aciduria with ketonuria. They may show in fasting, severe infection or ketolytic defect(ex, 3-ketothiolase deficiency). Patients with 3-ketothiolase deficiency, can develop seizures during fever, and fasting state. Therefore further evaluation is necessary.
Keywords: Seizures | Febrile | Acetyl CoA C-Acytransferase | Amino acid metabolism | Inborn errors | Lactic acid
TOOLS
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
Supplementary Material  Supplementary Material
  E-Mail
  Print
Share:      
METRICS
1,424
View
1
Download
Proteomic analysis of human serum from patients with temporal lobe epilepsy  2009 May;52(5)
Treatment and management of patients with inherited metabolic diseases  2006 November;49(11)
Clinical Analysis of Pediatric Death Patients Visiting Emergency Center  2004 January;47(1)
Clinical Analysis of Pediatric Death in Emergency Room  2001 September;44(9)
Congenital Heart Anomalies in Patients with Clefts of the Lip and/or Palate  2000 April;43(4)
Register for e-submission
Register here to access the e-submission system of Korean J Pediatr for authors and reviewers.
Manuscript Submission
To submit a manuscript, please visit the Korean J Pediatr e-submission management system at http://submit.kjp.or.kr, read the Instructions for Authors, and log into the Korean J Pediatr e-submission system. For assistance with manuscript submission, please contact: kjpped@gmail.com.
Free archive
Anyone may access any past or current articles without logging in.
Korean Pediatric Society Office
#1606, Seocho World Officetel, 19 Seoun-ro, Seocho-gu, Seoul 137-070, Korea
TEL : +82-2-3473-7305    FAX : +82-2-3473-7307   E-mail: kjpped@gmail.com
BrowseCurrent IssueFor Authors and ReviewersAbout
Copyright© The Korean Pediatric Society. All right reserved.