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Korean J Pediatr 2004 December;47(12) :1293-1299.
Cord blood Cytokines on the Development of Cerebral Palsy in Premature Infant
Ki Dae Kim (Kim KD), Byeong Hee Son (Son BH), Chang Whan Oh (Oh CW), Jung A Lee (Lee JA), Sung Won Kim (Kim SW)
Department of Pediatrics, St. Benedict Hospital, Busan, Korea
Corresponding Author: Byeong Hee Son ,Email:
Copyright © 2004 by The Korean Pediatric Society
Purpose : This study was performed to determine the relation between cord blood plasma cytokines responses and development of cerebral palsies in premature infants. Methods : Interleukin-1(IL-1), Interleukin-6(IL-6), Tumor necrosis factor-(TNF-) were measured using ELISA kits in premature infants(n=60) who were admitted to St. Benedict Hospital from September 2001 to June 2003. Retrospective study was done by review of medical records. Results : Cord blood levels of IL-1, IL-6 and TNF- in the cerebral palsy group were higher, especially IL-6 but were not significant, compared with the control group. Cord blood levels of IL-6 in the cerebral palsy without asphyxia, sepsis, PROM, RDS and pneumonia were significantly different, compared with the control group. Conclusion : Cord blood levels of IL-1, IL-6 and TNF- in the cerebral palsy group were increased, but concentrations of IL-6 increased significantly. Cord blood levels of IL-6 may be a useful value to predict the development of cerebral palsy, because they are related to IL-6 rather than to TNF- & IL-1 in this study.
Keywords: Cytokine | Interlukin(IL-1 | IL-6 | TNF-) | Cerebral palsy | Premature
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