Advanced Search
Korean J Pediatr 2006 January;49(1) :87-92.
Usefulness of serum procalcitonin test for the diagnosis of upper urinary tract infection in children
Dong Wook Kim (Kim DW)1, Ju Young Chung (Chung JY)1, Ja Wook Koo (Koo JW)1, Sang Woo Kim (Kim SW)1, Tae Hee Han (Han TH)2
1Department of Pediatrics Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea
2Department of Diagnostic Laboratory Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea
Corresponding Author: Ja Wook Koo ,Email:
Copyright © 2006 by The Korean Pediatric Society
Purpose : It is difficult to make a distinction between lower urinary tract infection(UTI) and acute pyelonephritis(APN) during the acute phase of febrile UTI due to nonspecific clinical symptoms and laboratory findings, especially among young children. We measured the serum procalcitonin(PCT) in children with UTI to distinguish between acute pyelonephritis and lower UTI, and to determine the accuracy of PCT measurement compared with other inflammatory markers. Methods : Serum samples were taken from children who admitted with unexplained fever or were suspected of having UTI. 51 children(mean 12.2?1.4 months) were enrolled in this study. Leukocyte counts, erythrocyte sedimentation rates(ESR) and C-reactive protein(CRP) were also measured. Renal parenchymal involvement was assessed by 99mTc DMSA scintigraphy in the first 7 days after admission. PCT was measured by immunoluminometric assay. Results : PCT values were significantly correlated with the presence of renal defects in children with UTI(n=16)(5.06?2.97 g/L, P<0.05). However, PCT values were not significantly different between children with UTI without renal damage(n=18) and children without UTI(n=17). Using a cutoff of 0.5 g/L for PCT and 20 mm/hr for ESR, 20 mg/L for CRP, sensitivity and specificity in distinguishing between UTI with and without renal involvement were 81.3 percent and 88.9 percent for PCT 87.5 percent and 72.2 percent for ESR, and 87.5 percent and 55.6 percent for CRP, respectively. Positive and negative predictive values were 86.7 percent and 84.2 percent for PCT and 60.9 percent and 81.8 percent for CRP, respectively. Conclusion : In febrile UTI, PCT values were more specific than CRP, ESR and leukocyte count for the identification of patients who might develop renal defects.
Keywords: Acute pyelonephritis | Procalcitonin | 99mTc DMSA scintigraphy | Urinary tract infection
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
Supplementary Material  Supplementary Material
Clinical usefulness of serum procalcitonin level in distinguishing between Kawasaki disease and other infections in febrile children  2017 April;60(4)
Usefulness of interferon- release assay for the diagnosis of latent tuberculosis infection in young children  2016 June;59(6)
Usefulness of neutrophil-lymphocyte ratio in young children with febrile urinary tract infection  2016 March;59(3)
Usefulness of pelvic ultrasonography for the diagnosis of central precocious puberty in girls  2015 August;58(8)
The usefulness of soluble transferrin receptor in the diagnosis and treatment of iron deficiency anemia in children  2015 January;58(1)
Register for e-submission
Register here to access the e-submission system of Korean J Pediatr for authors and reviewers.
Manuscript Submission
To submit a manuscript, please visit the Korean J Pediatr e-submission management system at, read the Instructions for Authors, and log into the Korean J Pediatr e-submission system. For assistance with manuscript submission, please contact:
Free archive
Anyone may access any past or current articles without logging in.
Korean Pediatric Society Office
#1606, Seocho World Officetel, 19 Seoun-ro, Seocho-gu, Seoul 137-070, Korea
TEL : +82-2-3473-7305    FAX : +82-2-3473-7307   E-mail:
BrowseCurrent IssueFor Authors and ReviewersAbout
Copyright© The Korean Pediatric Society. All right reserved.