Advanced Search
Korean J Pediatr 2006 March;49(3) :312-316.
The effect of growth hormone treatment in short children born small for their gestational ages
Joo Hee Seo (Seo JH), Duk Hee Kim (Kim DH)
Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea
Corresponding Author: Duk Hee Kim ,Email:
Copyright © 2006 by The Korean Pediatric Society
Purpose : Growth hormone(GH) has been recognized as an effective treatment for short children born small for their gestational ages(SGA), and nowadays it has been widely used for the treatment of short children born SGA. The aim of this study is to assess the efficacy of GH treatment for the children born SGA. Methods : The study population was made of 40 short children born SGA with GH-treated(n=26) and untreated control group(n=14). In order to evaluate the effect of GH treatment, the changes in standard deviation scores(SDS) of the GH-treated group were compared to the changes in SDS before and after treatment from the control group in the same period. Results : There were no differences between the GH-treated group and the control group in gestational age, birth weight, chronological age, target height and the period of follow-up observation; however, the GH-treated group had lower height SDS(-3.30.9) than the control group(-2.40.4) before treatment(P<0.05). The GH-treated group had gained 1.21.0 height SDS during GH treatment while the control group had gained 0.50.6 height SDS. In the GH treatment group, HDL- cholesterol increased from 48.59.9 mg/dL to 56.18.7 mg/dL(P<0.05) and LDL-cholesterol decreased from 88.123.3 mg/dL to 76.419.4 mg/dL(P<0.05) after treatment. There were no changes in total cholesterol, triglyceride, free fatty acid and fasting blood sugar. IGF-I increased from 224.9191.3 µg/L to 443.2152.5 µg/L(P<0.05) and IGFBP-3 also increased from 3.71.3 mg/L to 5.61.2 mg/L(P<0.05). Conclusion : We conclude that growth hormone treatment is effective in the treatment of short children born SGA.
Keywords: Infant | Small for gestational age | Growth hormone | Short stature
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
Supplementary Material  Supplementary Material
Behavioral and intelligence outcome in 8- to 16-year-old born small for gestational age  2016 October;59(10)
Catch-up growth and catch-up fat in children born small for gestational age  2016 January;59(1)
Efficacy and safety of growth hormone treatment for children born small for gestational age  2014 September;57(9)
Catch up growth in children born small for gestational age by corrected growth curve  2009 September;52(9)
Effect of growth hormone on neuronal death in hippocampal slice cultures of neonatal rats exposed to oxygen-glucose deprivation  2009 May;52(5)
Register for e-submission
Register here to access the e-submission system of Korean J Pediatr for authors and reviewers.
Manuscript Submission
To submit a manuscript, please visit the Korean J Pediatr e-submission management system at, read the Instructions for Authors, and log into the Korean J Pediatr e-submission system. For assistance with manuscript submission, please contact:
Free archive
Anyone may access any past or current articles without logging in.
Korean Pediatric Society Office
#1606, Seocho World Officetel, 19 Seoun-ro, Seocho-gu, Seoul 137-070, Korea
TEL : +82-2-3473-7305    FAX : +82-2-3473-7307   E-mail:
BrowseCurrent IssueFor Authors and ReviewersAbout
Copyright© The Korean Pediatric Society. All right reserved.