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Korean J Pediatr 2007 January;50(1) :74-78.
A clinical study of systemic lupus erythematosus in children
Ji Tae Kim (Kim JT), Young Mee Nam (Nam YM), Jae Seung Lee (Lee JS), Dong Soo Kim (Kim DS)
Department Of Pediatrics, Severance Children's Hospital, Yonsei University Medical Center, Seuol, Korea
Corresponding Author: Dong Soo Kim ,Email:
Copyright © 2007 by The Korean Pediatric Society
Purpose : Systemic lupus erythematosus (SLE) is a chronic multisystemic autoimmune disease with complex clinical manifestations. It probably involves genetic, environmental and immunologic factors. In this study, we investigated the clinical manifestations, laboratory findings and prognosis of pediatric SLE to aid clinical care of pediatric SLE. Methods : The data of 45 patients who were diagnosed as pediatric SLE in Severance Children's Hospital from Jan. 1996 to Dec. 2005 were analysed retrospectively. Results : The mean age at diagnosis was 10.8 (0-15) years old. And the ratio of male to female patients was 1:4. The initial manifestations were facial edema (51.1 percent), malar rash (44.4 percent), and fever (28.9 percent). The ANA (97.8 percent), anti-ds DNA antibody (82.2 percent), lupus nephritis (71.1 percent), malar rash (71.1 percent), and cytopenia (66.7 percent) were the most common findings among the classification criteria by ACR (American College of Rhematology, 1997). Conclusion : Clinical manifestations and prognosis are various in pediatric SLE. Intensive studies of SLE in children should be continued for more effective treatment.
Keywords: Systemic lupus erythematosus | Children | Adolescent
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