Advanced Search
Korean J Pediatr 2007 April;50(4) :369-375.
Analysis of urine 2-microglobulin in pediatric renal disease
Dong Woon Kim (Kim DW), In Seok Lim (Lim IS)
Department of Medical Science, Graduate School of Medicine, Chung-Ang University, Seoul, Korea
Corresponding Author: In Seok Lim ,Email:
Copyright © 2007 by The Korean Pediatric Society
Purpose : There have been numerous researches on urine 2-microglobulin (2-M) concerned with primary nephrotic syndrome and other glomerular diseases, but not much has been done in relation to pediatric age groups. Thus, our hospital decided to study the relations between the analysis of the test results we have conducted on pediatric patients and renal functions. Methods : Retrospective data analysis was done to 102 patients of ages 0 to 4 with renal diseases with symptoms such as hematuria, edema, and proteinuria who were admitted to Chung-Ang Yongsan Hospital and who participated in 24-hour urine and urine 2-M excretion test between January of 2003 and January of 2006. Each disease was differentiated as independent variables, and the statistical difference of the results of urine 2-M excretion of several groups of renal diseases was analyzed with student T-test by using test results as dependent variables. Results : Levels of urine 2-M excretion of the 102 patients were as follows : 52 had primary nephrotic syndrome [MCNS (n=45, 7245 g/g creatinine, g/g-Cr), MPGN (n=3, 154415 g/g-Cr), FSGS (n=4, 18846 g/-Cr)], six had APSGN (93404 g/g-Cr), seven had IgA nephropathy (3,414106 g/g-Cr), 9 had APN (742160 g/g-Cr), 16 had cystitis (179168 g/g-Cr), and 12 had HSP nephritis (109898 g/g-Cr). IgA nephropathy (P<0.05) and APN (P<0.05) were significantly higher than in other renal diseases. Among primary nephrotic syndrome, FSGS with higher results of 2-microglobulin test had longer treatment period (P<0.01) when compared to the lower groups, but no significant differences in Ccr, BUN, or Cr were observed. Conclusion : IgA nephropathy and APN groups showed significantly higher level of 2-M excretion value than other groups. Although 2-microglobulin value is not appropriate as an indicator of general renal function and pathology, it seems to be sufficient in the differential diagnosis of the UTI and in the prediction of the treat-ment period of nephrotic syndrome patients.
Keywords: Beta-2-microglobulin | Renal disease
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
Supplementary Material  Supplementary Material
Sensorineural hearing loss in patients with Kawasaki disease  2015 November;58(11)
Evaluation of Intrauterine Growth in Neonates with Congenital Heart Disease  2004 July;47(7)
The Utilities of Lung Biopsy in Pediatric Lung Disease  2003 December;46(12)
Analysis of Treatment in Pediatric Germ Cell Tumor  2002 January;45(1)
Analysis of Malnutrition in Children with Congenital Heart Disease  2001 February;44(2)
Register for e-submission
Register here to access the e-submission system of Korean J Pediatr for authors and reviewers.
Manuscript Submission
To submit a manuscript, please visit the Korean J Pediatr e-submission management system at, read the Instructions for Authors, and log into the Korean J Pediatr e-submission system. For assistance with manuscript submission, please contact:
Free archive
Anyone may access any past or current articles without logging in.
Korean Pediatric Society Office
#1606, Seocho World Officetel, 19 Seoun-ro, Seocho-gu, Seoul 137-070, Korea
TEL : +82-2-3473-7305    FAX : +82-2-3473-7307   E-mail:
BrowseCurrent IssueFor Authors and ReviewersAbout
Copyright© The Korean Pediatric Society. All right reserved.