Advanced Search
ORIGINAL ARTICLE
Korean J Pediatr 2008 June;51(6) :634-639.
doi:https://doi.org/10.3345/kjp.2008.51.6.634
A comparative study of the puberty suppression effect of gonadotropin-releasing hormone agonist in precocious or early puberty girls
Kye-Shik Shim (Shim KS)1, Chong-Woo Bae (Bae CW)1, You-Jung Yang (Yang YJ)2
1Departments of Pediatrics, College of Medicine, Kyunghee University, Seoul, Korea
2Departments of Nuclear Medicine, College of Medicine, Kyunghee University, Seoul, Korea
Corresponding Author: Kye-Shik Shim ,Email: 64sks@khnmc.or.kr.
Copyright © 2008 by The Korean Pediatric Society
ABSTRACT
Purpose : There has been considerable disagreement regarding the most appropriate dosage of gonadotropin-releasing hormone agonist in cases of central precocious puberty. The aim of this study was to determine the appropriate dosage for suppression of the puberty in girls with central precocious or early puberty. Methods : Twenty-two girls with early puberty were randomly subjected to 3 types of dosages of leuprolide acetate for at least 6 months. The number of cases in groups 1, 2, and 3 were 7, 7, and 8, and dosages were 70, 90, and 110 g/ kg/-month, respectively. Height, weight, bone age, Tanner stage of breast development, and serum levels of LH, FSH, estradiol, and progesterone were measured before treatment and after 6 months of treatment. The number of cases of puberty suppression was compared using a modified puberty suppression score with a nonparametric chi-square test. Results : There were no significant differences of chronologic and bone ages among the groups. There was a significant decrease in height SDS gain after 6 months in group 3 (P<0.05) compared with groups 1 and 2. Serum levels of LH, FSH, estradiol and progesterone were all significantly decreased after treatment in all 3 groups (P<0.05). The number of cases of puberty suppression in each group were 4 (57%), 5 (71%), and 8 (100%). There was a significantly increased proportion of suppression of puberty in group 3 (P<0.05). Conclusion : It was necessary to use a higher dose of gonadotropin-releasing hormone agonist to suppress early puberty in girls; however further longitudinal study will be needed for their prognosis of final adult height.
Keywords: Gonadotropin-releasing hormone agonist | Puberty suppression | Precocious puberty | Early puberty
TOOLS
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
Supplementary Material  Supplementary Material
  E-Mail
  Print
Share:      
METRICS
1,680
View
6
Download
The influence of gonadotropin-releasing hormone agonists on anthropometric change in girls with central precocious puberty  2017 December;60(12)
Long-term effects of gonadotropin-releasing hormone analogs in girls with central precocious puberty  2015 January;58(1)
The genes associated with gonadotropin-releasing hormone-dependent precocious puberty  2012 January;55(1)
Analysis of gonadotropin-releasing hormone (GnRH) test results in girls with precocious puberty  2009 December;52(12)
Growth promoting effect of combined gonadotropin releasing hormone analogue and growth hormone therapy in early pubertal girls with predicted low adult heights  2007 July;50(7)
Register for e-submission
Register here to access the e-submission system of Korean J Pediatr for authors and reviewers.
Manuscript Submission
To submit a manuscript, please visit the Korean J Pediatr e-submission management system at http://submit.kjp.or.kr, read the Instructions for Authors, and log into the Korean J Pediatr e-submission system. For assistance with manuscript submission, please contact: kjpped@gmail.com.
Free archive
Anyone may access any past or current articles without logging in.
Korean Pediatric Society Office
#1606, Seocho World Officetel, 19 Seoun-ro, Seocho-gu, Seoul 137-070, Korea
TEL : +82-2-3473-7305    FAX : +82-2-3473-7307   E-mail: kjpped@gmail.com
BrowseCurrent IssueFor Authors and ReviewersAbout
Copyright© The Korean Pediatric Society. All right reserved.