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ORIGINAL ARTICLE
Korean J Pediatr 2008 September;51(9) :1012-1017.
doi:https://doi.org/10.3345/kjp.2008.51.9.1012
Clinical significance of the mechanical properties of the abdominal aorta in Kawasaki disease
Mi Jin Kim (Kim MJ)1, Mi Jin Kim (Kim MJ)1, Sang Yun Lee (Lee SY)1, Sang Yun Lee (Lee SY)1, Yong Bum Kim (Kim YB)1, Yong Bum Kim (Kim YB)1, Hong Ryang Kil (Kil HR)1, Hong Ryang Kil (Kil HR)1
1Department of Pediatrics, College of Medicine, Chungnam National University, Daejeon, Korea
Corresponding Author: Hong Ryang Kil ,Email: gilhong@cnu.ac.kr
Copyright © 2008 by The Korean Pediatric Society
ABSTRACT
Purpose : This study aimed to assess the mechanical properties of the abdominal aorta in school-aged patients treated for Kawasaki disease and in normal, healthy children. Methods : This study examined 28 children with Kawasaki disease who had been followed up on and 30 healthy subjects of the same age and gender. We recorded systolic (Ps) and diastolic (Pd) blood pressure values and the aortic diameter at both minimum diastolic (Dd) and maximum systolic (Ds) expansion using two-dimensional echocardiography. These measurements were used to determine 1) aortic strain: S=(Ds-Dd)/Dd; 2) pressure strain elastic modulus: Ep=(Ps-Pd)/S; and 3) normalized Ep: Ep*=Ep/Pd. Results : Ep (P=0.008) and Ep* (P=0.043) of the Kawasaki disease group were relatively high compared to those of the control group. Ep (P=0.002) and Ep* (P=0.015) of patients with coronary aneurysm were also relatively high compared with those of patients without coronary aneurysm, but lipid profiles did not differ, except for homocysteine (P=0.008). Therefore, in patients with coronary aneurysm, aortic stiffness was higher, compared to not only the control group but also patients without coronary aneurysm. However, in patients without coronary aneurysm, aortic stiffness was not significant, different compared to the control group. Conclusion : Measuring aortic distensibility may be helpful in assessing the risk of early atheroscletic change in the long- term management of Kawasaki disease.
Keywords: Mucocutaneous lymph node syndrome | Abdominal aorta | Mechanical property | Children
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