Advanced Search
Korean J Pediatr 2009 September;52(9) :984-990.
Catch up growth in children born small for gestational age by corrected growth curve
Myung Ki Jung (Jung MK), Ji Eun Song (Song JE), Seung Yang (Yang S), Il Tae Hwang (Hwang IT), Hae Ran Lee (Lee HR)
Department of Pediatrics, College of Medicine, Hallym University, Seoul, Korea
Corresponding Author: Seung Yang ,Email:
Copyright © 2009 by The Korean Pediatric Society
Purpose:Being small for gestational age (SGA) is a risk factor of short stature in children. Genetic background such as mid-parental height (MPH) is known to influence growth of children born SGA. We studied the relationship between growth of children born SGA and MPH and studied the effects of insulin-like growth factor (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) on postnatal growth in children born SGA according to MPH. Methods:Forty-nine neonates born SGA were included in this study. We defined corrected height standard deviation score (cHtSDS) by modified height SDS (HtSDS) based on their MPH. We categorized subjects into group 1 consisting of children with cHtSDS 0 (n=35) and group 2 consisting of children with cHtSDS <0 (n=14), and compared IGF-I and IGFBP-3 between the two groups. Results:The HtSDSs and cHtSDSs in groups 1 and 2 were 0.061.05 vs. -0.950.85 (P=0.000) and 0.780.93 vs. -0.46 0.67 (P=0.000), respectively. IGF-I SDS was higher in group 1 than in group 2 (2.823.69 vs. 0.232.42, P=0.012). Total cHtSDS (0.421.03) was significantly higher than HtSDS (-0.221.10) (P=0.000). Conclusion:Our results show that cHtSDS differs significantly from HtSDS. Growth assessment by standardized growth curve does not uniformly show effects of genetic factors. A more accurate assessment of growth uses a personalized corrected growth curve that considers the genetic factor measured by MPH.
Keywords: Small for gestational age | Insulin-like growth factor | Insulin-like growth factor binding protein 3 | Catch up growth
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
Supplementary Material  Supplementary Material
Comparison of postnatal catch-up growth according to definitions of small for gestational age infants  2018 March;61(3)
Catch-up growth and catch-up fat in children born small for gestational age  2016 January;59(1)
Efficacy and safety of growth hormone treatment for children born small for gestational age  2014 September;57(9)
Consequences of being born small for gestational age : More than being small  2009 February;52(2)
Growth and sex differentiation of children born small for gestational age  2009 February;52(2)
Register for e-submission
Register here to access the e-submission system of Korean J Pediatr for authors and reviewers.
Manuscript Submission
To submit a manuscript, please visit the Korean J Pediatr e-submission management system at, read the Instructions for Authors, and log into the Korean J Pediatr e-submission system. For assistance with manuscript submission, please contact:
Free archive
Anyone may access any past or current articles without logging in.
Korean Pediatric Society Office
#1606, Seocho World Officetel, 19 Seoun-ro, Seocho-gu, Seoul 137-070, Korea
TEL : +82-2-3473-7305    FAX : +82-2-3473-7307   E-mail:
BrowseCurrent IssueFor Authors and ReviewersAbout
Copyright© The Korean Pediatric Society. All right reserved.