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Korean J Pediatr 2010 February;53(2) :253-257.
A case of atypical hemolytic uremic syndrome as an early manifestation of acute lymphoblastic leukemia
Dong Kyun Han (Han DK)1, Hee Jo Baek (Baek HJ)1, Young Kuk Cho (Cho YK)1, Chan Jong Kim (Kim CJ)1, Myung Geun Shin (Shin MG)2, Hoon Kook (Kook H)1, Tai Ju Hwang (Hwang TJ)1
1Departments of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju, Korea
2Departments of Laboratory Medicine, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju, Korea
Corresponding Author: Hoon Kook ,Tel: +82.61-379-7696, Fax: +82.61-379-7697, Email:
Copyright © 2010 by The Korean Pediatric Society
Hemolytic uremic syndrome (HUS) is the most common cause of acute renal failure in children younger than 4 years and is characterized by microangiopathic hemolytic anemia, acute renal failure, and thrombocytopenia. HUS associated with diarrheal prodrome is usually caused by Shiga toxin-producing Escherichia coli O157:H7 or by Shigella dysenteriae, which generally has a better outcome. However, atypical cases show a tendency to relapse with a poorer prognosis. HUS has been reported to be associated with acute lymphoblastic leukemia (ALL) in children. The characteristics and the mechanisms underlying this condition are largely unknown. In this study, we describe the case of an 11-year-old boy in whom the diagnosis of ALL was preceded by the diagnosis of atypical HUS. Thus, patients with atypical HUS should be diagnosed for the possibility of developing ALL.
Keywords: Hemolytic uremic syndrome | Acute lymphoblastic leukemia | Acute renal failure
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