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REVIEW ARTICLE
Korean J Pediatr 2013 May;56(5) :196-201.
Published online 2013 March 13.        doi:https://doi.org/10.3345/kjp.2013.56.5.196
Systemic use of fluoroquinolone in children
Soo-Han Choi1, Eun Young Kim2, Yae-Jean Kim3
1Department of Pediatrics, KEPCO Medical Foundation KEPCO Medical Center, Seoul, Korea
2Department of Clinical Pharmacy, College of Pharmacy, Chung-Ang University, Seoul, Korea
3Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Corresponding Author: Yae-Jean Kim ,Tel: +82-2-3410-3539, Fax: +82-2-3410-0043, Email: yaejeankim@skku.edu
Copyright © 2013 by The Korean Pediatric Society
ABSTRACT
Fluoroquinolones are an important class of antibiotics that are widely used in adult patients because of their broad spectrum of activity, good tissue penetration, and oral bioavailability. However, fluoroquinolone use in children is limited because juvenile animals developed arthropathy in previous experiments on fluoroquinolone use. Indications for fluoroquinolone use in patients younger than 18 years, as stated by the U.S. Food and Drug Administration, include treatment of complicated urinary tract infections and postexposure treatment for inhalation anthrax. In Korea, the systemic use of fluoroquinolones has not been approved in children younger than 18 years. Although concerns remain regarding the adverse musculoskeletal effects of fluoroquinolones in children, their use in the pediatric population has increased in many circumstances. While pediatricians should be aware of the indications and adverse effects of fluoroquinolones, recent studies have shown that the risk for musculoskeletal complications in children did not significantly increase following fluoroquinolone treatment. In addition, fluoroquinolones may be particularly helpful in treating multidrug-resistant infections that have not responded to standard antibiotic therapy in immunocompromised patients. In the present article, we provide an updated review on the safety and current recommendations for using fluoroquinolones in children.
Keywords: Fluoroquinolones | Adverse effects | Joint diseases | Child
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