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Korean J Pediatr 2015 January;58(1) :1-7.
Published online 2015 January 15.       
Long-term effects of gonadotropin-releasing hormone analogs in girls with central precocious puberty
Eun Young Kim
Department of Pediatrics, Chosun University School of Medicine, Gwangju, Korea
Corresponding Author: Eun Young Kim ,Tel: +82-62-220-3055, Fax: +82-62-227-2904, Email:
Copyright © 2015 by The Korean Pediatric Society
Gonadotropin-releasing hormone analogs (GnRHa) are widely used to treat central precocious puberty (CPP). The efficacy and safety of GnRHa treatment are known, but concerns regarding long-term complications are increasing. Follow-up observation results after GnRHa treatment cessation in female CPP patients up to adulthood showed that treatment (especially <6 years) was beneficial for final adult height relative to that of pretreated or untreated patients. Puberty was recovered within 1 year after GnRHa treatment discontinuation, and there were no abnormalities in reproductive function. CPP patients had a relatively high body mass index (BMI) at the time of CPP diagnosis, but BMI standard deviation score maintenance during GnRHa treatment seemed to prevent the aggravation of obesity in many cases. Bone mineral density decreases during GnRHa treatment but recovers to normal afterwards, and peak bone mass formation through bone mineral accretion during puberty is not affected. Recent studies reported a high prevalence of polycystic ovarian syndrome in CPP patients after GnRHa treatment, but it remains unclear whether the cause is the reproductive mechanism of CPP or GnRHa treatment itself. Studies of the psychosocial effects on CPP patients after GnRHa treatment are very limited. Some studies have reported decreases in psychosocial problems after GnRHa treatment. Overall, GnRHa seems effective and safe for CPP patients, based on long-term follow-up studies. There have been only a few long-term studies on GnRHa treatment in CPP patients in Korea; therefore, additional long-term follow-up investigations are needed to establish the efficacy and safety of GnRHa in the Korean population.
Keywords: Precocious puberty | Gonadotropin-releasing hormone | Follow-up studies
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The genes associated with gonadotropin-releasing hormone-dependent precocious puberty  2012 January;55(1)
Effects of human growth hormone on gonadotropin-releasing hormone neurons in mice  2010 September;53(9)
Clinical application of gonadotropin-releasing hormone analogs in children and adolescents  2010 March;53(3)
Analysis of gonadotropin-releasing hormone (GnRH) test results in girls with precocious puberty  2009 December;52(12)
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