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Korean J Pediatr 2016 April;59(4) :165-173.
Published online 2016 April 15.       
Modification of nutrition strategy for improvement of postnatal growth in very low birth weight infants
Ah Young Choi, Yong Wook Lee, Mea-young Chang
Department of Pediatrics, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea
Corresponding Author: Mea-young Chang ,Tel: +82-42-280-7253, Fax: +82-42-255-3158, Email:
Copyright © 2016 by The Korean Pediatric Society
Purpose: To identify the effects of modified parenteral nutrition (PN) and enteral nutrition (EN) regimens on the growth of very low birth weight (VLBW) infants.
Methods: The study included VLBW infants weighing <1,500 g, admitted to Chungnam National University Hospital between October 2010 and April 2014, who were alive at the time of discharge. Subjects were divided according to 3 periods: period 1 (n=37); prior to the PN and EN regimen being modified, period 2 (n=50); following the PN-only regimen modification, period 3 (n=37); following both PN and EN regimen modification. The modified PN regimen provided 3 g/kg/day of protein and 1 g/kg/ day of lipid on the first day of life. The modified EN regimen provided 3.5–4.5 g/kg/day of protein and 150 kcal/kg/day of energy. We investigated growth rate, anthropometric measurements at 40 weeks postconceptional age (PCA) and the incidence of extrauterine growth restriction (EUGR) at 40 weeks PCA.
Results: Across the 3 periods, clinical characteristics, including gestational age, anthropometric measurements at birth, multiple births, sex, Apgar score, surfactant use and PDA treatment, were similar. Growth rates for weight and height, from time of full enteral feeding to 40 weeks PCA, were higher in period 3. Anthropometric measurements at 40 weeks PCA were greatest in period 3. Incidence of weight, height and head circumference EUGR at 40 weeks PCA decreased in period 3.
Conclusion: Beginning PN earlier, with a greater supply of protein and energy during PN and EN, is advantageous for postnatal growth in VLBW infants.
Keywords: Parenteral nutrition | Enteral nutrition | Extrauterine growth restriction | Very low birth weight infant
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Supplementary Material  Supplementary Material
Postdischarge growth assessment in very low birth weight infants  2017 March;60(3)
Enteral nutrition for optimal growth in preterm infants  2016 December;59(12)
Nutritional strategy of early amino acid administration in very low birth weight infants  2015 March;58(3)
Evaluation of three glucometers for whole blood glucose measurements at the point of care in preterm or low-birth-weight infants  2015 August;58(8)
Thyroid dysfunction in very low birth weight preterm infants  2015 June;58(6)
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