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Korean J Pediatr 2016 April;59(4) :183-189.
Published online 2016 April 15.       
Correlation of B-type natriuretic peptide levels and echocardiographic parameters in preterm infants with patent ductus arteriosus
Hyun Ah Jeong, Jeonghee Shin, Eunji Kim, Eun Hee Lee, Byung Min Choi, Chang Sung Son, Joo Won Lee
Department of Pediatrics, Korea University College of Medicine, Seoul, Korea
Corresponding Author: Byung Min Choi ,Tel: +82-31-412-6557, Fax: +82-31-405-8591, Email:
Copyright © 2016 by The Korean Pediatric Society
Purpose: This study aimed to evaluate the correlation, according to postnatal age, between plasma B-type natriuretic peptide (BNP) levels and echocardiographic parameters for the assessment of patent ductus arteriosus (PDA) in preterm infants with respiratory distress.
Methods: We enrolled 42 preterm infants with respiratory distress who underwent serial echocardiographic evaluation with simultaneous plasma BNP measurements until ductal closure. The correlations between BNP levels and the following 4 representative echocardiographic parameters were studied: diameter of the ductus arteriosus (DA), ratio of the left atrial diameter to the aortic diameter (LA/Ao), ratio of the PDA diameter to the infants left pulmonary artery diameter (PDA/LPA), and the antegrade diastolic flow of LPA (DFLPA).
Results: BNP levels were significantly correlated to the magnitude of the ductal shunt, comprising the DA diameter, PDA/LPA ratio, LA/Ao ratio, and antegrade DFLPA for the overall study period. The earliest significant correlation, starting from postnatal day 2, was observed between the LA/Ao ratio and BNP levels. The PDA/LPA ratio and the antegrade DFLPA showed significant correlations with BNP levels postnatal day 3 onward, and with the DA diameter, postnatal day 5 onward.
Conclusion: BNP levels and echocardiographic parameters showed a positive correlation, but the significance of the correlations differed according to the postnatal age, especially during the first few days of life.
Keywords: Patent ductus arteriosus | B-type natriuretic peptide | Echocardiography | Premature infant
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Supplementary Material  Supplementary Material
B-type natriuretic peptide may have a role in the management of patent ductus arteriosus  2018 February;61(2)
Delayed closure effect in preterm infants with patent ductus arteriosus  2008 October;51(10)
Plasma B-type natriuretic peptide (BNP): a useful marker for anthracycline-induced cardiotoxicity in Korean children with cancer  2007 August;50(8)
The factors associated with the efficacy of indomethacin treatment in premature infants with patent ductus arteriosus  2007 June;50(6)
A Comparative Study of the Effects of Intravenous Indomethacin and Oral Mefenamic Acid in the Treatment of Premature Infants with Patent Ductus Arteriosus  2001 January;44(1)
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