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Korean J Pediatr 2016 December;59(12) :477-482.
Published online 2016 December 15.        doi:
Predictive factors of resistance to intravenous immunoglobulin and coronary artery lesions in Kawasaki disease
Hye Young Lee1, Min Seob Song2
1Department of Pediatrics, Good Gang-An Hospital, Busan, Korea
2Department of Pediatrics, Inje University Haeundae Paik Hospital, Busan, Korea
Corresponding Author: Min Seob Song ,Tel: +82-51-797-0652, Fax: +82-51-797-0649, Email:
Copyright © 2016 by The Korean Pediatric Society
Purpose: We conducted a study to determine which factors may be useful as predictive markers in identifying Kawasaki disease (KD) patients with a high risk of resistance to intravenous immunoglobulin (IVIG) and developing coronary artery lesions (CAL).
Methods: We enrolled 287 patients in acute phase of KD at a single center. The demographic, clinical and laboratory data were collected retrospectively.
Results: There were 34 patients in the IVIG resistant group. The IVIG resistant group had significantly higher serum N-terminal-pro-brain natriuretic protein (NT-proBNP) levels (P<0.01) and polymorphonuclear neutrophil (PMN) percentage (P<0.01) in comparison to the IVIG responders. The results yielded sensitivity (78.8%, 60.6%), specificity (58.2%, 90%) and cutoff value (628.6 pg/mL, 80.3%) of NT-proBNP and PMN respectively, in predicting IVIG resistance. Despite IVIG administration, 13 of the 287 patients developed CAL. The patients in the CAL group had higher NT-proBNP levels (P<0.01) and higher PMN percentage (P<0.01). In these patients, the results yielded sensitivity (73.3%, 56.7%), specificity (67.9%, 88.9%) and cutoff value (853.4 pg/mL, 80.3%) of NT-proBNP and PMN respectively, for predicting CAL. The area under the curve (AUC) for predicting resistance to IVIG was NT-proBNP 0.712, PMN 0.802. The AUC for predicting CAL was NT-proBNP 0.739, and PMN 0.773.
Conclusion: Serum NT-proBNP levels and PMN percentage were significantly elevated in patients with KD with IVIG resistance and CAL. Thus, they may be useful predicting markers for IVIG resistance and development of CAL in KD patients.
Keywords: Kawasaki disease | Immunoglobulin | Coronary artery | Pro-brain natriuretic protein | Neutrophils
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Supplementary Material  Supplementary Material
Relationship between vitamin D levels and intravenous immunoglobulin resistance in Kawasaki disease  2017 July;60(7)
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Meta-analysis of factors predicting resistance to intravenous immunoglobulin treatment in patients with Kawasaki disease  2016 February;59(2)
Predictors of nonresponse to intravenous immunoglobulin therapy in Kawasaki disease  2013 February;56(2)
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