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ORIGINAL ARTICLE
Korean J Pediatr 2017 July;60(7) :216-220.
Published online 2017 July 15.       
Relationship between vitamin D levels and intravenous immunoglobulin resistance in Kawasaki disease
Jae Sung Jun, Young Kwon Jung, Dong Won Lee
Department of Pediatrics, Daegu Fatima Hospital, Daegu, Korea
Corresponding Author: Dong Won Lee ,Tel: +82-53-940-7520, Fax: +82-53-940-7524, Email: rabitover@hanmail.net
Copyright © 2017 by The Korean Pediatric Society
ABSTRACT
Purpose: Vitamin D is associated with various pathological conditions such as cardiovascular diseases and cancer. We investigated the relationship between vitamin D and Kawasaki disease (KD).
Methods: We performed a retrospective review of the medical records of patients with KD between February 2013 and March 2016 in Daegu Fatima Hospital. Study participants were grouped according to vitamin D serum concentration. Group 1 included patients with 25(OH)-vitamin D 20 ng/mL. Group 2 included patients with 25(OH)-vitamin D <20 ng/mL. We analyzed the clinical characteristics and laboratory data of the 2 groups.
Results: Of the 91 patients, 52 were included in group 1, and 39 in group 2. Group 1 patients had significantly higher levels of calcium, phosphate, albumin and sodium than group 2 patients did. There were no differences in clinical characteristics, but the proportion of patients with polymorphic rash was significantly higher in group 2. Resistance to intravenous immunoglobulin was more frequent in group 2 (P= 0.023). No significant difference in the incidence of coronary artery complications was observed.
Conclusion: Low vitamin D levels are associated with resistance to intravenous immunoglobulin therapy in KD. Vitamin D deficiency might be a risk factor for immunoglobulin resistance in KD.
Keywords: Vitamin D | Kawasaki disease | Inflammation
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Relationship between serum sodium level and coronary artery abnormality in Kawasaki disease  2017 February;60(2)
Predictive factors of resistance to intravenous immunoglobulin and coronary artery lesions in Kawasaki disease  2016 December;59(12)
Prediction of unresponsiveness to second intravenous immunoglobulin treatment in patients with Kawasaki disease refractory to initial treatment  2016 October;59(10)
Prediction of nonresponsiveness to medium-dose intravenous immunoglobulin (1 g/kg) treatment: an effective and safe schedule of acute treatment for Kawasaki disease  2016 April;59(4)
Meta-analysis of factors predicting resistance to intravenous immunoglobulin treatment in patients with Kawasaki disease  2016 February;59(2)
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