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Korean J Pediatr 2017 December;60(12) :395-402.
Published online 2017 December 15.       
The influence of gonadotropin-releasing hormone agonists on anthropometric change in girls with central precocious puberty
Jong Wan Yoon1, Hyun A Park1, Jieun Lee1, Jae Hyun Kim2
1Department of Pediatrics, Inje University Ilsan Paik Hospital, Goyang, Korea
2Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea
Corresponding Author: Jieun Lee ,Tel: +82-31-910-7101, Fax: +82-31-910-7108, Email:
Copyright © 2017 by The Korean Pediatric Society
Purpose: The potential effect of gonadotropin-releasing hormone agonist (GnRHa) treatment on the weight of girls with central precocious puberty (CPP) remains a controversy. We investigated anthropometric changes during and after GnRHa treatment among girls with CPP.
Methods: This retrospective study evaluated data from 127 girls with CPP who received GnRHa treatment for 2 years. Height, weight, and body mass index (BMI) values were compared at the baseline (visit 1), after 1 year of GnRHa treatment (visit 2), the end of GnRHa treatment (visit 3), and 6–12 months after GnRHa discontinuation (visit 4).
Results: The height z score for chronological age (CA) increased continuously between visit 1 and visit 4. No significant differences were observed in BMI z score for CA between visits 1 and 4. However, an increasing trend in the BMI z score for bone age (BA) was observed between visits 1 and 4. The numbers of participants who were of normal weight, overweight, and obese were 97, 22, and 8, respectively, at visit 1, compared to 100, 16, and 11, respectively, at visit 4 (P=0.48).
Conclusion: Among girls with CPP, the overall BMI z score for CA did not change significantly during or after GnRHa treatment discontinuation, regardless of their BMI status at visit 1. However, the BMI z score for BA showed an increasing trend during GnRHa treatment and a decreasing trend after discontinuation. Therefore, long-term follow-up of BMI changes among girls with CPP is required until they attain adult height.
Keywords: Precocious puberty | Gonadotropin-releasing hormone agonist | Body mass index | Obesity
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Supplementary Material  Supplementary Material
Long-term effects of gonadotropin-releasing hormone analogs in girls with central precocious puberty  2015 January;58(1)
The genes associated with gonadotropin-releasing hormone-dependent precocious puberty  2012 January;55(1)
Clinical application of gonadotropin-releasing hormone analogs in children and adolescents  2010 March;53(3)
Analysis of gonadotropin-releasing hormone (GnRH) test results in girls with precocious puberty  2009 December;52(12)
A comparative study of the puberty suppression effect of gonadotropin-releasing hormone agonist in precocious or early puberty girls  2008 June;51(6)
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