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Korean J Pediatr 2018 January;61(1) :12-16.
Published online 2018 January 15.       
C-reactive protein and N-terminal pro-brain natriuretic peptide discrepancy: a differentiation of adenoviral pharyngoconjunctival fever from Kawasaki disease
Jung Eun Choi, Hee Won Kang, Young Mi Hong, Sejung Sohn
Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea
Corresponding Author: Sejung Sohn ,Tel: +82-2650-5579, Fax: +82-2653-3718, Email:
Copyright © 2018 by The Korean Pediatric Society
Purpose: To differentiate adenoviral pharyngoconjunctival fever (PCF) from acute Kawasaki disease (KD) using laboratory tests before results of virus-real time polymerase chain reaction and ophthalmologic examination are obtained.
Methods: Baseline patient characteristics and laboratory measurements were compared between 40 patients with adenovirus infection and 123 patients with KD.
Results: The patients with adenovirus infection were generally older than those with KD (median: 3.9 years vs. 2 years, P=0.000). White blood cell and, platelet count, and aspartate aminotransferase, alanine aminotransferase, and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels showed significant differences between the 2 groups, but the C-reactive protein (CRP) levels did not (6.83.0 mg/dL vs. 8.35.8 mg/dL, P=0.126). In the adenovirus infection group, the CRP levels were <1, <3, <10, and 10 mg/dL in 2 (5%), 3 (7.5%), 30 (75%), and 5 patients (12.5%), respectively. The cutoff NT-proBNP level was 265 pg/mL. Discrepancy was defined as CRP and NT-proBNP levels of 3 or <3 mg/dL, and <265 or 265 pg/mL, respectively. Among the 35 patients with adenovirus infection whose CRP levels were 3 mg/dL, 29 (82.9%) showed a discrepancy. Conversely, of the 103 patients with KD whose CRP levels were 3 mg/dL, 83 (80.6%) showed no discrepancy. Between the groups, a significant difference in discrepancy rate was observed (P=0.000). None of the patients with adenovirus infection had CRP and NT-proBNP levels of <3 mg/dL and 265 pg/mL, respectively.
Conclusion: With a sensitivity of 82.9% and a specificity of 80.6%, CRP and NT-proBNP levels may differentiate between adenoviral PCF and acute KD.
Keywords: Adenovirus | Kawasaki disease | C-reactive protein | NT-proBNP | Discr
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Supplementary Material  Supplementary Material
Age-adjusted plasma N-terminal pro-brain natriuretic peptide level in Kawasaki disease  2016 July;59(7)
Clinical characteristics and serum N-terminal pro-brain natriuretic peptide as a diagnostic marker of Kawasaki disease in infants younger than 3 months of age  2014 August;57(8)
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