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Korean J Pediatr 2018 March;61(3) :90-94.
Published online 2018 March 15.       
Association between vitamin D and urinary tract infection in children
Abolfazl Mahyar1, Parviz Ayazi1, Sara Safari1, Reza Dalirani2, Amir Javadi3, Shiva Esmaeily3
1Qazvin Children Hospital, Qazvin University of Medical Sciences, Qazvin, Iran
2Mofid Children Hospital, Pediatric Nephrology Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Statistic Department, Qazvin University of Medical Sciences, Qazvin, Iran
Corresponding Author: Abolfazl Mahyar ,Tel: +982813334807-9, Fax: +982813344088, Email:
Copyright © 2018 by The Korean Pediatric Society
Purpose: The present study aimed to determine the relationship between serum 25-hydroxyvitamin D (25(OH)D) level and Urinary tract infections (UTIs) in children.
Methods: In this case-control study, 70 children with UTI (case group) were compared with 70 healthy children (control group) in terms of serum 25(OH)D levels. The children were between 1 month and 12 years of age. Serum 25(OH)D levels were measured using enzyme-linked immunosorbent assay (ELISA). The results were analyzed and compared between both groups.
Results: Among 70 children with UTI (case group), 5 children (7.2%) were male and 65 (92.8%) were female. Among the healthy children (control group), 9 (12.8%) and 61 children (87.2%) were male and female, respectively (P=0.39). The meanstandard deviation of age in the case and control groups were 53.235.6 and 36.160.2 months, respectively (P=0.24). The mean level of serum 25(OH)D in the case group was significantly higher than that of the control group (20.48.6 ng/mL vs. 16.97.4 ng/mL, P= 0.01)
Conclusion: This study showed that there was a relationship between serum 25(OH)D levels and UTI in children. It seems that 25(OH)D plays a role in the pathogenesis of UTI.
Keywords: 25-Hydroxyvitamin D | Urinary tract infection | Child
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