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ORIGINAL ARTICLE
Korean J Pediatr 2018 May;61(5) :156-159.
Published online 2018 May 15.       
Diagnostic and prognostic value of proadrenomedullin in neonatal sepsis
Sameh Samir Fahmey1, Heba Mostafa1, Noha Abd Elhafeez2, Heba Hussain1
1Pediatrics Department, Beni-Suef University, Beni Suef, Egypt
2Clinical and Chemical Pathology Department, Beni-Suef University, Beni Suef, Egypt
Corresponding Author: Sameh Samir Fahmey ,Tel: +20-1289732856, Fax: +20-227539322, Email: ssfahmey34@yahoo.com
Copyright © 2018 by The Korean Pediatric Society
ABSTRACT
Purpose: Sepsis is a major cause of neonatal morbidity and mortality. Early diagnosis is a major problem because of the lack of specific clinical signs. Therefore, a reliable diagnostic marker is needed to guide the use of antimicrobial agents. The objective of our study was to assess the value of proadrenomedullin (pro-ADM) in establishing the diagnosis and evaluating the prognosis of neonatal sepsis.
Methods: This study enrolled 60 newborn infants with sepsis proven with positive blood cultures and 30 healthy neonates. Complete blood count, C-reactive protein levels, and pro-ADM levels were obtained from all neonates.
Results: The pro-ADM levels were significantly higher (14.390.75 nmol/L) in the sepsis group than in the control group (3.120.23 nmol/L). The optimal cutoff value for pro-ADM was 4.3 nmol/L, with a sensitivity of 93.3% and a specificity of 86.7%. The pro-ADM levels were also higher in nonsurvivors (P=0.001).
Conclusion: Pro-ADM can be used as a reliable biomarker for neonatal sepsis. High pro-ADM levels were associated with mortality and could be an early indicator of disease outcome.
Keywords: Neonate | Proadrenomedullin | Sepsis | Marker
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