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ORIGINAL ARTICLE
Korean J Pediatr 2018 May;61(5) :160-166.
Published online 2018 May 15.       
Clinical implications in laboratory parameter values in acute Kawasaki disease for early diagnosis and proper treatment
Yu-Mi Seo1, Hyun-Mi Kang1,2, Sung-Churl Lee1, Jae-Won Yu3, Hong-Ryang Kil3, Jung-Woo Rhim1,2, Ji-Whan Han1, Kyung-Yil Lee1,2
1Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea
1,2Department of Pediatrics, Daejeon St. Marys Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea
3Department of Pediatrics, Chungnam National University Hospital, School of Medicine, Chungnam National University, Daejeon, Korea
Corresponding Author: Kyung-Yil Lee ,Tel: +82-42-220-9540, Fax: +82-42-221-2925, Email: leekyungyil@catholic.ac.kr
Copyright © 2018 by The Korean Pediatric Society
ABSTRACT
Purpose: This study aimed to analyse laboratory values according to fever duration, and evaluate the relationship across these values during the acute phase of Kawasaki disease (KD) to aid in the early diagnosis for early-presenting KD and incomplete KD patients.
Methods: Clinical and laboratory data of patients with KD (n=615) were evaluated according to duration of fever at presentation, and were compared between patients with and without coronary artery lesions (CALs). For evaluation of the relationships across laboratory indices, patients with a fever duration of 5 days or 6 days were used (n=204).
Results: The mean fever duration was 6.62.3 days, and the proportions of patients with CALs was 19.3% (n=114). C-reactive proteins (CRPs) and neutrophil differential values were highest and hemoglobin, albumin, and lymphocyte differential values were lowest in the 6-day group. Patients with CALs had longer total fever duration, higher CRP and neutrophil differential values and lower hemoglobin and albumin values compared to patients without CALs. CRP, albumin, neutrophil differential, and hemoglobin values at the peak inflammation stage of KD showed positive or negative correlations each other.
Conclusion: The severity of systemic inflammation in KD was reflected in the laboratory values including CRP, neutrophil differential, albumin, and hemoglobin. Observing changes in these laboratory parameters by repeated examinations prior to the peak of inflammation in acute KD may aid in diagnosis of earlypresenting KD patients.
Keywords: Kawasaki disease | C-reactive protein | Albumin | Hemoglobin | Coronary artery lesion
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