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Korean J Pediatr 2012 June;55(6) :193-201.
Published online 2012 June 15.        doi:
Effects of probiotics on the prevention of atopic dermatitis
Nam Yeun Kim (Kim NY), Geun Eog Ji (Ji GE)
Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University College of Human Ecology, Seoul, Korea
Corresponding Author: Geun Eog Ji ,Tel: +82-2-880-8749, Fax: +82-2-884-0305, Email:
Copyright © 2012 by The Korean Pediatric Society
Atopic dermatitis (AD) is an immune disorder that is becoming increasingly prevalent throughout the world. The exact etiology of AD remains unknown, and a cure for AD is not currently available. The hypothesis that appropriate early microbial stimulation contributes to the establishment of a balanced immune system in terms of T helper type Th1, Th2, and regulatory T cell (Treg) responses has led to the use of probiotics for the prevention and treatment of AD in light of various human clinical studies and animal experiments. Meta-analysis data suggests that probiotics can alleviate the symptoms of AD in infants. The effects of balancing Th1/Th2 immunity and enhancing Treg activity via the interaction of probiotics with dendritic cells have been described in vitro and in animal models, although such an effect has not been demonstrated in human studies. In this review, we present some highlights of the immunomodulatory effects of probiotics in humans and animal studies with regard to their effects on the prevention of AD.
Keywords: Probiotics | Dermatitis | Atopic | Prevention | Immunomodulation | Immune system
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