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Korean J Pediatr 2014 February;57(2) :75-78.
Published online 2013 August 28.       
Clinical features of macrocephaly at birth in Korea
Goun Jeong1, Minkyun Kim1, Byoung Hee Han2
1Departments of Pediatrics, Cheil General Hospital & Womens Healthcare Center, Seoul, Korea
2Departments of Radiology, Cheil General Hospital & Womens Healthcare Center, Seoul, Korea
Corresponding Author: Goun Jeong ,Tel: +82-2-2000-7274, Fax: +82-2-2000-7614, Email:
Copyright © 2014 by The Korean Pediatric Society
Purpose: This study aimed to investigate the clinical features of macrocephaly at birth in Korea using ultrasonography.
Methods: We retrospectively investigated the medical records of full-term birth neonates in Cheil General Hospital & Womens Healthcare Center from January 2000 to June 2012. The following parameters were recorded and analyzed: gestational age, sex, birth weight, height, occipitofrontal circumference (OFC), physical examination, perinatal problems, and ultrasonography results. Macrocephaly was diagnosed when the OFC was greater than two standard deviations, based on the 2007 Korean National Growth Charts.
Results: There were 75 neonates with macrocephaly at birth (52 boys and 23 girls), with a mean OFC of 38.10.49 cm. A comparison of the birth weight and height with the OFC value showed that height was correlated with OFC (r=0.35) but birth weight was not correlated with OFC (r=0.06). There were no remarkable findings in 56 cases (75%). Germinal matrix hemorrhage was identified in 10 cases (13%). An enlarged cerebrospinal fluid space was found in 5 cases (6.7%). There were 3 cases of mega-cisterna magna (4%), 1 case of ventriculomegaly, and 1 case of an enlarged interhemispheric space (6 mm) among these patients. In addition, a choroid plexus cyst was seen in 1 case. Mineralizing vasculopathy in both basal ganglia with no evidence of congenital infection was found in 2 cases and an asymptomatic subarachnoid hemorrhage was found in 1 case.
Conclusion: Our results indicate that macrocephaly at birth has benign ultrasonography findings and shows a pattern of male dominance.
Keywords: Macrocephaly | Growth charts | Newborn | Ultrasonography
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