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Korean J Pediatr 2015 June;58(6) :230-233.
Published online 2013 August 28.       
A novel association between cerebral sinovenous thrombosis and nonketotic hyperglycinemia in a neonate
Sadk Yurttutan1, Mehmet Yekta Oncel1, Nursel Yurttutan2, Halil Degirmencioglu1, Nurdan Uras1, Ugur Dilmen3
1Neonatal Intensive Care Unit, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey
2Elmadağ State Hospital, Ankara, Turkey
3Department of Pediatrics, Yldrm Beyazt University Hospital, Ankara, Turkey
Corresponding Author: Sadk Yurttutan ,Tel: +90-312-3065271, Fax: +90-312-2362101, Email:
Copyright © 2015 by The Korean Pediatric Society
Lethargy in newborns usually indicates central nervous system dysfunction, and many conditions such as cerebrovascular events, infections, and metabolic diseases should be considered in the differential diagnosis. Nonketotic hyperglycinemia is an autosomal recessive error of glycine metabolism, characterized by myoclonic jerks, hypotonia, hiccups, apnea, and progressive lethargy that may progress to encephalopathy or even death. Cerebral sinovenous thrombosis is a rare condition with various clinical presentations such as seizures, cerebral edema, lethargy, and encephalopathy. Here, we report the case of a newborn infant who presented with progressive lethargy. An initial diagnosis of cerebral venous sinus thrombosis was followed by confirmation of the presence of nonketotic hyperglycinemia.
Keywords: Newborn | Nonketotic hyperglycinemia | Cranial venous sinus thrombosis
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The relation between angiotensin converting enzyme (ACE) gene polymorphism and neonatal hyperbilirubinemia in Korea  2007 January;50(1)
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