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Journal of the Korean Pediatric Society 1992;35(3):399-405.
Published online March 15, 1992.
A Case of Dermatomyositis Remitted with Cyclosporin A
Jo Won Jung1, Ki Soo Pai1, Pyung-Kil Kim1, Woo Hee Jung2
1Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea
2Department of Parthology, Yonsei University College of Medicine, Seoul, Korea
Cyclosporin A 투여로 호전된 피부근염 1례
정조원1, 배기수1, 김병길1, 정우희2
1연세대학교 의과대학 소아과학교실
2연세대학교 의과대학 해부병리학교실
Abstract
Cyclosporin A has highly selective immunce suppressive action through inhibition of the production of interleukin 2 by helper T-cells. A case of dermatomyositis remitted with cyclosporin A in a 2-year-old girl is reported. She was admitted due to progressive weakness of lower extremities and facial flushing. The diagnosis was made by typical clinical findings with aids of laboratory data, electromyographic and muscle biopsy findings. Initially her clinical syptoms and laboratory findings were improved with oral steriod medication (2mg/kg/day in four divided dose) and physiotherapy, but progressively aggrevated again 2 weeks after the begin of sterioid maintenance therapy (1mg/kg/day). So, we tried cyclosporin A combined with alternate day prednisolone therapy (1mg/kg), then she was remitted without any complication. A brief review of related literatures has been done.
Key Words: Dermatomyositis, Cyclosporin A


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