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Journal of the Korean Pediatric Society 1994;37(10):1357-1363.
Risk Factors of Bronchopulmonary Dysplasia in Premature Infants Treated with Mechanical Ventilation and Restrictive Fluid Therapy
Min Soo Park, Kook In Park, Hye Jung Choo, Moon Sung Park, Ran Namgung, Chul Lee, Dong Gwan Han
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea
제한적 수액요법을 시행한 호흡부전증 미숙아에서 기관지폐이형성증 발병위험인자에 관한 연구
박민수, 박국인, 주혜정, 박문성, 남궁란, 이철, 한동관
연세대학교 의과대학 소아과학교실
In addition to many of the widely accepted risk factors of bronchopulmonary dysplasia(BPD), such as prematurity, oxygen toxicity, barotrauma, and infection, the amount of fluid intake during the early phase of life has recently been reported to be an important factor, especially the amount of colloid. Forty-one premature infants who were admitted to the NICU of Severance Hospital, Yonsei University College of Medicine between Jan. 1990 and Jun. 1992 and treated for respiratory difficulty with mechanical ventilation and restrictive fluid therapy were included in the study. Fourteen were diagnosed as BPD and the rest were grouped as Non-BPD. We confirmed prematurity, low birth weight, high oxygen concentration, high ventilator pressures and rates, perinatal asphyxia, acidosis, and low blood pressures as risk factors. However, with restrictive fluid therapy that we have used, there was no difference in the amount of total fluid, of crystalloid, or of colloid between BPD and Non-BPD groups, as were the urine output, serum electrolyte concentrations, and percent body weight change. The amount of colloid when used for the maintenance of adequated blood pressures and for the prevention and treatment of hypovolemia, oliguria, anemia of sepsis under the scheme of restrictive fluid therapy would not influence adversely in the development of BPD. Instead, the amount of colloid used may imply the severity of illness of the patient; that is, the more sevenre the condition of the patient the more the amount of colloid used.
Key Words: Bronchopulmonary dysplasia(BPD), Colloids


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