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Journal of the Korean Pediatric Society 1995;38(10):1329-1339.
A Study of Antimicrobial Sensitivity to Isolated Bacteria in Ulsan
Sun Ju Kim1, Yong Woon Baek1, Jin Yeong Jeong1, Sung Ryul Kim2
1Department of Pediatrics, Haesung General Hospital, Ulsan, Korea
2Department of Clinical Pathology, Haesung General Hospital, Ulsan, Korea
울산지역에서 최근 분리된 세균에 대한 항생제 감수성 검사의 고찰
김선주1, 백용운1, 정진영1, 김성률2
1아산재단 해성병원 소아과
2아산재단 해성병원 임상병리과
Abstract
Purpose
: The Patterns of predominant microorganisms and their antibiotic sensitivity have been changed by various factors. Identification and evaluation of major pathogenic organisms and selection of optimal antibiotics were essential in the management of infectious diseases. This susceptibility patterns of antibiotics would be useful to improve empirical antimicrobial therapy.
Methods
: We studied the antimicrobial sensitibity to isolated bacteria from specimens requested for microbiologic culture from January 1990 to June 1994 at Pediaric department in Haesung General hospital in Ulsan. There were used 11 antibiotics for gram-positive organisms; Augmentin, Clindamycin, Oxacillin, Penicillin, Tetracycline, Ampicillin, Piperacillin, Cephalothin, Ciprofloxacin, Bactrim, Vancomycin. And there were used 6 antibiotics for gram-negative organisms; Gentamicin, Amikacin, Tobramycin, Cefotrixon, Cefotetan, Imipenem.
Results
: 1) In 3,656 isolated strains, 123 strains were isolated in blood cultures. In this cultures, E. coli was isolated in 27 cases(15.0%), Coagulase negative staphylococcus in 27 cases(15.0%), Staphylococcus aures in 14 cases(11.3%), Salmonella species in 14cases(11.3%) and Enterococcus cloacae in 14 cases(11.3%). 3210 strains were isolated in urine cultures. In this cultures, E. coli was isolated in 1235 cases(38.5%), Coagulase negative staphylococcus in 553 cases(17.2%), Enterococcus faecalis in 484 cases(15.0%) and Staphylococcus aureus in 352 cases(11.0%). 20 strains were isolated in stool cultures. In this cultures, Salmonella species was isolated in 6 cases(45.0%), E. coli in 4 cases(20.0%), Morganella morganii in 4 cases(20.0%) and Proteus mirabilis in 3 cases(15.0%). The other 6 strains were isolated in CSF cultures. In this cultures, Proteus mirabilis was isolated in 2 cases(33.5%), Hemophilus influenza in 2cases(33.5%), Coagulase negative staphylococcus in 1 cases(16.5%) and β-Hemolytic streptococcus in 1 cases(16.5%). 2) There were 93 strains isolated in blood cultures of newborn infants. 52 strains were isolated in newborn infant under 7 days old. In these newborn infants E. coli were isolated in 19 cases(36.5%), Enterobacter cloacae in 17 cases(13.5%) and Proteus mirabilis in 5 cases(9.6%). The other 41 strains were isolated in newborn infants above 7days of old. In the newborn infants Coagulase negative staphylococcus were isolated in 17 cases(41.51%), Staphylococcus aureus in 9 cases(22.0%) and β-hemolytic streptococcus in 3 cases(7.3%). 3) In our study, the sensitivity to Salmonella species of ampicillin or amikacin had markedly decresed.
Conclusion
: Ampicillin had decreasedItheir sensitivity of the species of gram positive organisms, Gentamycin had gradually decreased their sensitivity to the species of gram negative organisms but amikacin has sensitivity to gram negative organisms.
Key Words: Antimicrobial therapy, Antibiotic sensitivity, Pediatric


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