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Journal of the Korean Pediatric Society 2000;43(10):1323-1329.
Published online October 15, 2000.
Epidemiologic Characteristics of T Serotyping in Relation to the Outbreak of Erythromycin Resistant Streptococcus pyogenes
Sung-Ho Cha2, Kyu Jam Hwang1, Young Hee Lee1
1Laboratory of Molecular Bacteriology, National Institute of Health, Seoul, Korea
2Department of Pediatrics, Kyung Hee College of Medicine, Seoul, Korea
Erythromycin 내성 A군 연쇄구균 출현과 관련된 세포벽 T 단백 항원성 검사의 역학적 중요성
차성호2, 황규잠1, 이영희1
1국립보건원 분자세균과
2경희대학교 의과대학 소아과학교실
Correspondence:  Sung-Ho Cha,
Email: tcha0319@netsgo.com
Abstract
Purpose
: The identification of antigenic specificity of Streptococcus pyogenes using T serotyping is important to understand biologic characteristics of microorganisms. We would like to disover the association of the occurrence of predominant T type, with possible outbreak of erythromycin resistant Streptococcus pyogenes in this country, which has been documented since the late 1990s.
Methods
: Throat swab cultures were taken from a total of 1,294 normal school children(Subject A) in two different geographical areas. A total of 92 strains(Subject B) were obtained from the patients with group A streptococcal infections from Jan. 1998 to Dec. 1998. All strains were serotyped with T protein antisera.
Results
: The distribution of T12 in Uljin increased from 4.2%(1996) to 45.7%(1998). T4 increased from 6.3% to 20.0%. Thirty-eight out of 92 strains were resistant to erythromycin. Twenty-seven out of 41 strains(T12) were multidrug resistant to erythromycin, clindamycin, and tetracycline.
Conclusion
: We can see the sudden increase in T12 strains, one of the strains that are resistant to erythromycin in 1998, compared with previous years. T protein serotyping could be epidemiologically useful as a screening methods for detecting erythromycin resistant group A streptococci in hospitals where the routine antibiotic sensitivity test dose not examin for streptococci.
Key Words: Streptococcus pyogenes, Erythromycin, T serotype, Antibiotic sensitivity test, Epidemiology
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