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Journal of the Korean Pediatric Society 2001;44(11):1305-1310.
Published online November 15, 2001.
A Case of Polio-like Encephalomyelitis Associated with Enterovirus 71 Infection
Hyun Kyung Roh1, Hee Jung Chung2, Young Mee Jee3, Doo Sung Cheon3
1Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea
2Department of Pediatrics, National Health Insurance Corporation, Ilsan Hospital, Koyang, Korea
3Department of Virology, Laboratory of Enteroviruses, National Institute of Health, Seoul, Korea
Enterovirus 71 감염과 관련된 Polio-like Encephalomyelitis 1례
노현경1, 정희정2, 지영미3, 천두성3
1연세대학교 의과대학 소아과학교실
2국민건강보험관리공단 일산병원 소아과
3국립보건원 바이러스부 소화기 바이러스과
Correspondence:  Hee Jung Chung,
Email: agathac@NHIMC.or.kr
Abstract
Enterovirus 71(EV71), like polioviruses, invades the central nervous system to give rise to aseptic meningitis, encephalitis or myelitis. EV71 was first isolated in California in 1969 from a 9-month- old infant with encephalitis. Since then it has been isolated from the brain of children who died of encephalitis and from feces of patients with meningitis, encephalitis or paralysis. Related strains have been isolated from outbreaks of similar diseases in Australia, Sweden, Bulgaria and Hungary. We have experienced polio-like encephalomyelitis in a 3-month-old girl. Initial brain MR imaging showed tissue destruction in the bilateral posterior portions of the medulla oblongata and the bilateral anterior horns of cervical spinal cord from C3 to C6 level. Follow-up MR imaging was performed 3 months later, which showed minimal residual change on the anterior horn of the cervical spinal cord at C4 level only. This report deals with rare polio-like encephalomyelitis associated with EV71 and discusses its diagnosis and management. Brain stem and cervical spinal cord involvement are characteristic findings of EV encephalomyelitis.
Key Words: Enterovirus 71, Polio-like encephalomyelitis, Serious CNS complications


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