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Journal of the Korean Pediatric Society 2003;46(12):1207-1211.
Plasma L-Arginine Concentration, Oxygenation Index and Pulmonary Artery Pressure in Premature Infants with Respiratory Distress Syndrome
Kyong Ah Jeong, Soon Ju Lee, In Kyung Sung, Chung Sik Chun
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea
호흡곤란 증후군 미숙아에서 혈중 L-arginine 농도와Oxygenation Index 및 폐동맥압과의 관계
정경아, 이순주, 성인경, 전정식
가톨릭대학교 의과대학 소아과학교실
Correspondence:  Soon Ju Lee,
Email: sunjulee@catholic.ac.kr
Abstract
Purpose
: This study was performed to observe the relationship of plasma L-arginine level and the severity of disease and pulmonary artery pressure in respiratory distress syndrome of premature infants.
Methods
: Peripheral blood samples were obtained at 1st, 3rd and 7th day from 21 premature infants with respiratory distress syndrome to analyze the L-arginine concentration. Oxygenation index (OI), an indicator of the severity of the disease, was calculated at the same time of the blood sampling. And pulmonary artery pressure was measured by Doppler echocardiography at each period. Plasma L-arginine level, OI and right ventricular systolic time interval(RVSTI) were analyzed.
Results
: Plasma L-arginine concentration of the 1st day was lower than 3rd and 7th day. OI and RVSTI were significantly correlated with each other(r=0.772, P<0.01). Plasma L- arginine level was correlated with oxygenation index(r=-0.346, P<0.01) and RVSTI(r=-0.416, P<0.01).
Conclusion
: Plasma L-arginine level was lowest in the 1st day during the study period. Plasma L- arginine concentration correlated significantly with the severity of respiratory distress syndrome and pulmonary artery pressure in premature infants.
Key Words: RDS, L-arginine, Oxygenation index, Pulmonary artery pressure


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