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Journal of the Korean Pediatric Society 2003;46(12):1260-1265.
Published online December 15, 2003.
Effect of Delayed Intensification on Survival of Childhood Acute Lymphoblastic Leukemia
Jie Yeon Lee1, Sue Youn1, Byoung Chul Kwon2, Chuhl Joo Lyu2, Hwang Min Kim1
1Department of Pediatrics, Wonju College of Medicine, Yonsei University, Wonju, Korea
2Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea
소아기 급성 림프구성 백혈병에서 후기강화요법의 효과
이지연1, 윤수1, 권병철2, 유철주2, 김황민1
1연세대학교 원주의과대학 소아과학교실
2연세대학교 의과대학 소아과학교실
Correspondence:  Hwang Min Kim,
Email: khm9120@wonju.yonsei.ac.kr
Abstract
Purpose
: In 1970, the Berlin-Frankfurt-Munster(BFM) group introduced an intensification therapy after remission induction to reduce relapse of acute lymphoblastic leukemia(ALL) in childhood. Delayed intensification(DI) phase has been included for treatment of ALL in our hospital since the mid-1990s. The purpose of this study is to evaluate the outcome with vs. without DI phase and the outcome with two vs. one DI phase for intermediate risk patients.
Methods
: One hundred and thirty nine children with ALL who were treated at the Department of Pediatrics of Wonju Christian Hospital and Yonsei University Medical Center between March, 1990 and July, 2002 were analysed retrospectively.
Results
: Thirty-eight patients were treated with a DI phase, and 101 patients were treated without a DI phase. Among the DI patients, seven patients were treated with a double DI phase. Five-year overall survival(OS) in the low, intermediate, and high risk groups were 68%, 66% and 58%, respectively. 5-year OS in DDI, DI, and control were 95%, 86% and 40%, respectively. In the low risk group, 5-year event free survival(EFS) in DI, and control were 94% and 58%, respectively.
Conclusion
: Delayed intensification improved EFS on childhood ALL in all risk groups.
Key Words: Acute lymphoblastic leukemia, Delayed intensification, Childhood


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