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Korean Journal of Pediatrics 2006;49(6):617-622.
Published online June 15, 2006.
Serum high sensitivity C-reactive protein levels in obese middle school boys
Jae-Ho Jeong, Jae-Woo Lim, Eun-Jeong Cheon, Kyong-Og Ko, Young-Hyuk Lee
Department of Pediatrics, College of Medicine, Konyang University, Daejeon, Korea
남자 중학생에서 비만과 high sensitiviy C-reactive protein의 관계
정재호, 임재우, 천은정, 고경옥, 이영혁
건양대학교 의과대학 소아과학교실
Correspondence:  Eun-Jeong Cheon,
Email: kcm1000@kyuh.co.kr
Abstract
Purpose
: High-Sensitivity C-reactive protein(hs-CRP) has been recognized as a very useful and sensitive predictor of the future risk of myocardial infarction. But the clinical significance of hs-CRP in children remains uncertain. To confirm the existence of obesity-induced vascular inflammation and the association between metabolic syndromes and elevation of CRP in children, we investigated the relationship among CRP, obesity, blood pressure(BP), and serum lipids in schoolboys.
Methods
: Twenty-eight obese(BMI 29.61¡¾3.29 kg/m2) and 93 non-obese(BMI 18.99¡¾2.21 kg/m2) boys aged 14 years were examined. Serum CRP levels was measured by the high sensitive latex turbidimetric immunoassay and subjects with CRP levels below 0.3 mg/dL were adopted to avoid the influence of acute infection.
Results
: Obese children had significantly higher hs-CRP levels than their non-obese group(0.104¡¾0.075 vs. 0.054¡¾0.005 mg/dL). In the obese group, BMI, systolic blood pressure, diastolic blood pressure, apolipoprotein B, atherogenic index, and triglyceride were significantly higher than in non- obese. The BMI, diastolic blood pressure, apolipoprotein E, atherognic index, and triglyceride showed positive correlation with log CRP by simple regression. Multiple regression analysis indicated that BMI and apolipoprotein E were strongly related to CRP.
Conclusion
: This study revealed that obese children tended to have higher levels of serum hs- CRP, BP elevation and dyslipidemia than the control group and that BMI and apolipoprotein E were strongly related to CRP. These results indicate that obesity related metabolic syndrome can be developed in children.
Key Words: Obesity , hs-CRP , Metabolic syndrome
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