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Korean Journal of Pediatrics 2006;49(11):1211-1215.
Published online November 15, 2006.
Short-term follow up of thyroid function after pediatric hematopoietic stem cell transplantation
Seon-Ju Lee1, Jae-Wook Lee1, Dae-Hyoung Lee1, Young-Joo Kwon1, Young-Shil Park2, Hui Sung Hwang1, Sun Young Kim3, Ji Kyoung Park4, Pil-Sang Jang1, Min-Ho Jung1, Nak-Gyun Chung1, Dae-Chul Jeong1, Bin Cho1, Hack-Ki Kim1, Byung-Churl Lee1
1Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul
2Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul
3Department of Pediatrics, Busan Paik Hospital, College of Medicine, Inje University, Busan, Korea
4Department of Pediatircs, College of Medicine, Chungnam National University, Daejeon
소아 조혈모세포이식 후 단기간 갑상선 기능의 변화
이선주1, 이재욱1, 이대형1, 권영주1, 박영실2, 황희승1, 김선영3, 박지경4, 장필상1, 정민호1, 정낙균1, 정대철1, 조빈1, 김학기1, 이병철1
1가톨릭대학교 의과대학 소아과학교실
2경희대학교 의과대학 소아과학교실
3인제대학교 의과대학 부산백병원 소아과
4충남대학교 의과대학 소아과학교실
Correspondence:  Bin Cho,
Email: chobinkr@catholic.ac.kr
Abstract
Purpose
: In this study, we analyzed the short term changes of thyroid function, incidence and risk factors of thyroid dysfunction soon after allogeneic hematopoietic stem cell transplantation (HSCT) in children.
Methods
: We enrolled 80 pediatric patients following allogeneic HSCT, at the Catholic HSCT center between January, 2004 and February, 2006. Serum TSH (thyroid stimulating hormone), total serum thyroxine and total serum triiodothyronine levels were systematically measured in 80 patients before the HSCT, and at 1 month, 6 months and 12 months after HSCT.
Results
: Thyroid function statistically decreased at 1 month after HSCT(P<0.001). Thyroid dysfunction at 1 month was observed in 43 (54 percent) of 80 patients, 31 (39 percent) of whom presented with euthyroid sick syndrome (ETS). Thyroid dysfunction was normalized within 1 year after HSCT. In univariate analysis, malignant disease and the presence of acute graft-versus-host disease (grade ≥II) were risk factors for ETS (P=0.04, 0.01 respectively). In multivariate analysis, we could not detect an independent risk factor for ETS (P=0.19, 0.06 respectively).
Conclusion
: The present study suggests that the incidence of thyroid dysfunction is high after allogeneic HSCT. Therefore, regular monitoring of thyroid hormone levels after HSCT is required.
Key Words: Thyroid function , Euthyroid sick syndrome , Hematopoietic stem cell transplantation


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