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Korean Journal of Pediatrics 2008;51(5):523-527.
Published online May 15, 2008.
Transforming growth factor-β gene promoter polymorphism : its association with renal involvement in Henoch-Sch lein Purpura in childhood
Seung Ho Lee1, Hwa Young Jee1, Hwang Min Kim1, Byung Il Yeh2
1Department of Pediatrics, Wonju College of Medicine, Yonsei University, Wonju, Korea
2Department of Biochemistry, Wonju College of Medicine, Yonsei University, Wonju, Korea
소아 Henoch-Sch lein purpura에서 전환성장인자-β 프로모터유전자의 유전학적 다형성과 신장침범의 관련성
이승호1, 지화영1, 김황민1, 예병일2
1연세대학교 원주의과대학 소아과학교실
2연세대학교 원주의과대학 생화학교실
Correspondence:  Hwang Min Kim,
Email: khm9120@yonsei.ac.kr
Abstract
Purpose
: Several cytokines play important roles in the inflammatory process of Henoch-Sch lein Purpura (HSP). It is likely that transforming growth factor-β (TGF-β) is involved in the pathogenesis of HSP. The purpose of this study is to investigate whether TGF-β promoter polymorphism is associated with the renal involvement of childhood HSP.
Methods
: Thirty-four patients younger than 15 years, who had been diagnosed with HSP, as well as 27 controls, were examined. Patients and controls were genotyped for TGF-β C-509T by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Results
: The T allelic frequencies in patients and controls showed no difference (45% vs. 48.8%). No allele or genotype differences between the group of HSP group and control group were observed. The frequencies of TGF-β 509 genotypes TT, TC, and CC were no different between patients and controls (26% vs. 22%). The TT genotype of polymorphism of the TGF-β C-509T gene had no relation to the susceptibility of children to HSP and renal involvement in HSP.
Conclusion
: TGF-β T allele may not be related to the susceptibility of children to HSP. The TT genotype of polymorphism of the TGF-β C 509T gene does not appear to have an influence on renal involvement in childhood HSP.
Key Words: Henoch-Sch lein Purpura, TGF-β polymorphism, Renal involvement


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